ROLE OF BRAIN-DERIVED NEUROTROPHIC FACTOR RECEPTOR ON THE ANXIETY LEVELS IN RATS FOLLOWING THE ACUTE ADMINISTRATION OF MORPHINE

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Khali Khalili Masoumeh; GHODRATI JALDBAKHAN SHAHRBANOO; RASHIDY POUR ALI; BANDEGI AHMAD REZA; YOUSEFI BEHPOOR; MILADI GORJI HOSSEIN

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Journal: Koomesh Year:2016 | Volume:17 | Issue:3 (59) Page(s): 718-724

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Title

ROLE OF BRAIN-DERIVED NEUROTROPHIC FACTOR RECEPTOR ON THE ANXIETY LEVELS IN RATS FOLLOWING THE ACUTE ADMINISTRATION OF MORPHINE

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Keywords

ACUTE MORPHINEQ1

BDNF RECEPTOR ANTAGONIST (ANA12)Q1

ANXIETYQ2

Abstract

Introduction: The aim of this study was to examine anxiolytic effects of ACUTE MORPHINE and the role of BDNF receptor on that effect in adult rats.Materials and Methods: In this experiment, 48 adult male Wistar rats (200–250 g) were randomly assigned to six groups. Rats were given an acute dose of morphine (10 mg/kg, s.c.) and after 2hours, single dose of ANA12 (BDNF receptor antagonist) was injected (0.25, 0.5 mg/kg, i.p). After 4h, rats were examined in the EPM to assess the level of their ANXIETY. Control rats similarly received saline.Results: An increase was observed in the percentage of time spent in the open arm in the saline rats receiving ANA12 injection. However, the number of open or closed arm entries was less and more, respectively, in the morphine rats receiving ANA12 injection.Conclusion: Our findings showed a modulatory role of BDNF/TrkB receptor in the anxiolytic effects of ACUTE MORPHINE.

Cites

EFFECTS OF FORCED TREADMILL EXERCISE DURING THE INDUCTION OF MORPHINE DEPENDENCE ON THE SEVERITY OF PHYSICAL AND PSYCHOLOGICAL DEPENDENCE IN MORPHINE-DEPENDENT RATS

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APA: Copy

Khali Khalili, Masoumeh, GHODRATI JALDBAKHAN, SHAHRBANOO, RASHIDY POUR, ALI, BANDEGI, AHMAD REZA, YOUSEFI, BEHPOOR, & MILADI GORJI, HOSSEIN. (2016). ROLE OF BRAIN-DERIVED NEUROTROPHIC FACTOR RECEPTOR ON THE ANXIETY LEVELS IN RATS FOLLOWING THE ACUTE ADMINISTRATION OF MORPHINE. KOOMESH, 17(3 (59)), 718-724. SID. https://sid.ir/paper/36886/en

Vancouver: Copy

Khali Khalili Masoumeh, GHODRATI JALDBAKHAN SHAHRBANOO, RASHIDY POUR ALI, BANDEGI AHMAD REZA, YOUSEFI BEHPOOR, MILADI GORJI HOSSEIN. ROLE OF BRAIN-DERIVED NEUROTROPHIC FACTOR RECEPTOR ON THE ANXIETY LEVELS IN RATS FOLLOWING THE ACUTE ADMINISTRATION OF MORPHINE. KOOMESH[Internet]. 2016;17(3 (59)):718-724. Available from: https://sid.ir/paper/36886/en

IEEE: Copy

Masoumeh Khali Khalili, SHAHRBANOO GHODRATI JALDBAKHAN, ALI RASHIDY POUR, AHMAD REZA BANDEGI, BEHPOOR YOUSEFI, and HOSSEIN MILADI GORJI, “ROLE OF BRAIN-DERIVED NEUROTROPHIC FACTOR RECEPTOR ON THE ANXIETY LEVELS IN RATS FOLLOWING THE ACUTE ADMINISTRATION OF MORPHINE,” KOOMESH, vol. 17, no. 3 (59), pp. 718–724, 2016, [Online]. Available: https://sid.ir/paper/36886/en

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