A KINETIC STUDY ON CHANGES OF MOUSE PERIPHERAL BLOOD LYMPHOCYTE SUBSETS AFTER ADMINISTRATION OF T-2 TOXIN

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SALIMIAN JAFAR; POURSASAN NAJMEH; AZIZI JALILIAN FARID; KOKHAEI PARVIZ; DALILAN SONA

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Journal: Koomesh Year:2015 | Volume:16 | Issue:2 (54) Page(s): 260-265

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Title

A KINETIC STUDY ON CHANGES OF MOUSE PERIPHERAL BLOOD LYMPHOCYTE SUBSETS AFTER ADMINISTRATION OF T-2 TOXIN

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FLOW CYTOMETRYQ2

KINETICSQ2

LYMPHOCYTE SUBSETSQ2

T-2 TOXINQ2

Abstract

Introduction: T-2 mycotoxin, makes contamination in food and feed and causes poisoning in human and livestock. T-2 TOXIN induces serious effect on immune system cells. In this study, kinetic of blood peripheral LYMPHOCYTE SUBSETS after T-2 TOXIN exposure was investigated.Materials and Methods: In this experimental study, sublethal dose of T-2 TOXIN was determined and then injected into male mice. 12, 24, 48 and 72 h after toxin injection, a boold sample was taken from experimental anaimals. Afterward, KINETICS of lymphocyte subpopulations such as CD19+, CD3+, CD4+ and CD8+cells were analyzed using FLOW CYTOMETRY.Results: Sublethal dose of T-2 TOXIN was determined as 2 mg/kg. After sublethal dose injection CD19+ B cell significantly was decreased at 12 h and was returned to normal range at 3th day post-injection. CD3+ and CD4+ T populations increased at 24 h and were returned to normal range at 48 h, but inversely CD8+ T cells was decreased at 12 h and returned to to normal limit at 48 h.Conclusion: Alteration on blood lymphocytes due to T-2 TOXIN was occurred in 12 to 24 h postinjection. CD19+ and CD8+ lymphocytes were sensitive cells to toxin effect. CD3+ and CD4+ populations were increased. This may be due to pro-inflammatory cytokine release. T-2 TOXIN has different effects on kinetic of peripheral blood lymphocyte populations.

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APA: Copy

SALIMIAN, JAFAR, POURSASAN, NAJMEH, AZIZI JALILIAN, FARID, KOKHAEI, PARVIZ, & DALILAN, SONA. (2015). A KINETIC STUDY ON CHANGES OF MOUSE PERIPHERAL BLOOD LYMPHOCYTE SUBSETS AFTER ADMINISTRATION OF T-2 TOXIN. KOOMESH, 16(2 (54)), 260-265. SID. https://sid.ir/paper/37147/en

Vancouver: Copy

SALIMIAN JAFAR, POURSASAN NAJMEH, AZIZI JALILIAN FARID, KOKHAEI PARVIZ, DALILAN SONA. A KINETIC STUDY ON CHANGES OF MOUSE PERIPHERAL BLOOD LYMPHOCYTE SUBSETS AFTER ADMINISTRATION OF T-2 TOXIN. KOOMESH[Internet]. 2015;16(2 (54)):260-265. Available from: https://sid.ir/paper/37147/en

IEEE: Copy

JAFAR SALIMIAN, NAJMEH POURSASAN, FARID AZIZI JALILIAN, PARVIZ KOKHAEI, and SONA DALILAN, “A KINETIC STUDY ON CHANGES OF MOUSE PERIPHERAL BLOOD LYMPHOCYTE SUBSETS AFTER ADMINISTRATION OF T-2 TOXIN,” KOOMESH, vol. 16, no. 2 (54), pp. 260–265, 2015, [Online]. Available: https://sid.ir/paper/37147/en

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