EFFECTS OF MECAMYLAMINE (A NICOTINIC RECEPTOR ANTAGONIST) ON HARMAN INDUCED-AMNESIA IN AN INHIBITORY AVOIDANCE TEST

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NASEHI MOHAMMAD; PIRI MORTEZA; SHARIFI SHAHRBANO; SHAHIN MARYAM SADAT; ZARRINDAST MOHAMMAD REZA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2011 | Volume:13 | Issue:1(41) Page(s): 100-17

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

718

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF MECAMYLAMINE (A NICOTINIC RECEPTOR ANTAGONIST) ON HARMAN INDUCED-AMNESIA IN AN INHIBITORY AVOIDANCE TEST

Author(s)

Keywords

HARMANEQ3

MECAMYLAMINEQ2

AMNESIAQ2

DORSAL HIPPOCAMPUSQ2

MICEQ2

Abstract

Introduction: b-carbolines alkaloids such as HARMANE have been found in common plant-derived foodstuffs (wheat, rice, corn, barley, grape and mushrooms). These alkaloids have many cognitive effects including alteration short and long term memory. In the present study, the effect of intra-CA1 injection of the nicotinic receptor antagonist MECAMYLAMINE on AMNESIA induced by HARMANE was examined in MICE.Materials and Methods: MICE were bilaterally implanted with chronic cannulae in the CA1 regions of the DORSAL HIPPOCAMPUS. One week after cannulae implantation, MICE were trained in a step-down type inhibitory avoidance task, and were tested 24 h after training to measure step-down latency as a scale of memory.Results: Pre-training or post-training systemic injection of HARMANE induced AMNESIA. Pre-testing intra-dorsal hippocampus administration of the high dose of nicotinic receptor antagonist, MECAMYLAMINE (4 µg/mice) also induced AMNESIA. On the other hand, pre-test intra-CA1 injection of ineffective doses of MECAMYLAMINE (0.5, 1 and 2 µg/mice) fully restored HARMANE induced AMNESIA.Conclusion: The present finding in this study indicated that a complex interaction exists between nicotinic receptor of DORSAL HIPPOCAMPUS and AMNESIA induced by HARMANE.

Cites

No record.

References

No record.

Cite

APA: Copy

NASEHI, MOHAMMAD, PIRI, MORTEZA, SHARIFI, SHAHRBANO, SHAHIN, MARYAM SADAT, & ZARRINDAST, MOHAMMAD REZA. (2011). EFFECTS OF MECAMYLAMINE (A NICOTINIC RECEPTOR ANTAGONIST) ON HARMAN INDUCED-AMNESIA IN AN INHIBITORY AVOIDANCE TEST. KOOMESH, 13(1(41)), 100-17. SID. https://sid.ir/paper/380325/en

Vancouver: Copy

NASEHI MOHAMMAD, PIRI MORTEZA, SHARIFI SHAHRBANO, SHAHIN MARYAM SADAT, ZARRINDAST MOHAMMAD REZA. EFFECTS OF MECAMYLAMINE (A NICOTINIC RECEPTOR ANTAGONIST) ON HARMAN INDUCED-AMNESIA IN AN INHIBITORY AVOIDANCE TEST. KOOMESH[Internet]. 2011;13(1(41)):100-17. Available from: https://sid.ir/paper/380325/en

IEEE: Copy

MOHAMMAD NASEHI, MORTEZA PIRI, SHAHRBANO SHARIFI, MARYAM SADAT SHAHIN, and MOHAMMAD REZA ZARRINDAST, “EFFECTS OF MECAMYLAMINE (A NICOTINIC RECEPTOR ANTAGONIST) ON HARMAN INDUCED-AMNESIA IN AN INHIBITORY AVOIDANCE TEST,” KOOMESH, vol. 13, no. 1(41), pp. 100–17, 2011, [Online]. Available: https://sid.ir/paper/380325/en

Related Journal Papers