INTERACTION BETWEEN HARMANE AND NICOTINIC IN THE PASSIVE AVOIDANCE TEST

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PIRI M.; NASEHI M.; SHAHIN M.S.; ZARRINDAST M.R.

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Journal: Armaghane Danesh Year:2011 | Volume:15 | Issue:4 (60) Page(s): 366-377

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Title

INTERACTION BETWEEN HARMANE AND NICOTINIC IN THE PASSIVE AVOIDANCE TEST

Author(s)

PIRI M. | NASEHI M. | SHAHIN M.S. | ZARRINDAST M.R. | Issue Writer Certificate

Keywords

HARMANEQ3

NICOTINIC RECEPTORQ3

MEMORYQ2

MICEQ2

Abstract

Introduction & Objective: A number of b-carboline alkaloids such as HARMANE are naturally present in the human food chain. Furthermore, some plants which contain b-carboline have behavioral effects such as hallucination. In the present study, the effect of intra-dorsal hippocampus injection of NICOTINIC RECEPTOR agonist on MEMORY impairment induced by HARMANE was examined in MICE.Materials & Methods: This study was conducted at Shahid Beheshti University in 2009. Two hundred and forty MICE were anesthetized with intra-peritoneal injection of ketamine hydrochloride, plus xylazine which afterwards were placed in a stereotaxic apparatus. Two cannuale were placed in the CA1 regions of the dorsal hippocampus. All animals were allowed to recover for a total week before beginning of the behavioral testing. After that, the animals were trained in a step-down type inhibitory avoidance task and tested 24 hours after training to measure stepdown latency as a scale of MEMORY.Results: Pre-training and post-training, intra-peritoneal injection of HARMANE impairs inhibitory avoidance MEMORY, but pre-testing injection of HARMANE did not alter MEMORY retrieval. Pre-testing administration of high dose of nicotine (0.5 mg/mice, intra-CA1) decreased MEMORY retrieval. On the other hand, pre-test intra-CA1 injection of ineffective doses of nicotine (0.1 and 2.5 mg/mice) fully reversed HARMANE induced impairment of MEMORY.Conclusion: The present results indicated that complex interaction exists between NICOTINIC RECEPTOR of dorsal hippocampus and the impairment of inhibitory avoidance MEMORY induced by HARMANE.

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APA: Copy

PIRI, M., NASEHI, M., SHAHIN, M.S., & ZARRINDAST, M.R.. (2011). INTERACTION BETWEEN HARMANE AND NICOTINIC IN THE PASSIVE AVOIDANCE TEST. ARMAGHAN DANESH, 15(4 (60)), 366-377. SID. https://sid.ir/paper/77521/en

Vancouver: Copy

PIRI M., NASEHI M., SHAHIN M.S., ZARRINDAST M.R.. INTERACTION BETWEEN HARMANE AND NICOTINIC IN THE PASSIVE AVOIDANCE TEST. ARMAGHAN DANESH[Internet]. 2011;15(4 (60)):366-377. Available from: https://sid.ir/paper/77521/en

IEEE: Copy

M. PIRI, M. NASEHI, M.S. SHAHIN, and M.R. ZARRINDAST, “INTERACTION BETWEEN HARMANE AND NICOTINIC IN THE PASSIVE AVOIDANCE TEST,” ARMAGHAN DANESH, vol. 15, no. 4 (60), pp. 366–377, 2011, [Online]. Available: https://sid.ir/paper/77521/en

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