INVOLVEMENT OF NITRIC OXIDE SYSTEM OF DORSAL HIPPOCAMPUS ON HARMAN INDUCED-AMNESIA IN THE PASSIVE AVOIDANCE TEST

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PIRI MORTEZA; NASEHI MOHAMMAD; ABDOLAHIYAN MOZHGAN; SHAHIN MARYAM SADAT; ZARRINDAST MOHAMMAD REZA

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2011 | Volume:29 | Issue:137 Page(s): 505-517

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Title

INVOLVEMENT OF NITRIC OXIDE SYSTEM OF DORSAL HIPPOCAMPUS ON HARMAN INDUCED-AMNESIA IN THE PASSIVE AVOIDANCE TEST

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Keywords

HARMANEQ3

L-ARGININEQ2

L-NAMEQ2

AMNESIAQ2

DORSAL HIPPOCAMPUSQ2

MICEQ2

Abstract

Background: b-carbolines alkaloids such as HARMANE have been found in common plant-derived foodstuffs such as wheat, rice, corn, barley, grape and mushrooms. These alkaloids have many cognitive effects including alteration short and long term memory. In the present study, the effect of intra-CA1 injection of nitric oxide agonist and antagonist on AMNESIA induced by HARMANE was examined in MICE.Methods: In this experimental study 305 adult male NMRI MICE were used. MICE were anaesthetized and cannulae implanted bilaterally in the CA1 regions of the DORSAL HIPPOCAMPUS using stereotaxic method. One week after cannulae implantation, MICE trained in a step-down type inhibitory avoidance task, and tested 24 h after training to measure step-down latency as a scale of memory.Findings: Pre-training systemic injection of HARMANE induced AMNESIA. Pre-test intra-dorsal hippocampal injection of L-ARGININE (8 mg/mouse) or L-NAME (10 and 15 mg/mouse) potentiate and reverse AMNESIA induced by pre-training HARMANE, respectively, but pretraining injection of L-ARGININE or L-NAME 5 min before HARMANE could not block HARMANE AMNESIA.Conclusion: The finding in this study indicated that exist complex interaction between nitric oxide system of DORSAL HIPPOCAMPUS and AMNESIA induced by HARMANE.

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APA: Copy

PIRI, MORTEZA, NASEHI, MOHAMMAD, ABDOLAHIYAN, MOZHGAN, SHAHIN, MARYAM SADAT, & ZARRINDAST, MOHAMMAD REZA. (2011). INVOLVEMENT OF NITRIC OXIDE SYSTEM OF DORSAL HIPPOCAMPUS ON HARMAN INDUCED-AMNESIA IN THE PASSIVE AVOIDANCE TEST. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 29(137), 505-517. SID. https://sid.ir/paper/50151/en

Vancouver: Copy

PIRI MORTEZA, NASEHI MOHAMMAD, ABDOLAHIYAN MOZHGAN, SHAHIN MARYAM SADAT, ZARRINDAST MOHAMMAD REZA. INVOLVEMENT OF NITRIC OXIDE SYSTEM OF DORSAL HIPPOCAMPUS ON HARMAN INDUCED-AMNESIA IN THE PASSIVE AVOIDANCE TEST. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2011;29(137):505-517. Available from: https://sid.ir/paper/50151/en

IEEE: Copy

MORTEZA PIRI, MOHAMMAD NASEHI, MOZHGAN ABDOLAHIYAN, MARYAM SADAT SHAHIN, and MOHAMMAD REZA ZARRINDAST, “INVOLVEMENT OF NITRIC OXIDE SYSTEM OF DORSAL HIPPOCAMPUS ON HARMAN INDUCED-AMNESIA IN THE PASSIVE AVOIDANCE TEST,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 29, no. 137, pp. 505–517, 2011, [Online]. Available: https://sid.ir/paper/50151/en

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