Evaluation of COX-2 Expression in Colorectal Carcinoma in Patients Undergoing Colectomy in Ahvaz Imam Khomeini Hospital

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SHABANI MOHSEN; Kheradmand Parvin

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Journal: Jundishapur Scientific Medical Journal Year:2020 | Volume:19 | Issue:2 Page(s): 177-186

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Title

Evaluation of COX-2 Expression in Colorectal Carcinoma in Patients Undergoing Colectomy in Ahvaz Imam Khomeini Hospital

Author(s)

SHABANI MOHSEN | Kheradmand Parvin | Issue Writer Certificate

Keywords

Colorectal CancerQ1

COX2 FactorQ1

Tumor GradeQ1

Tumor StageQ1

MetastasisQ2

Abstract

Background and Objective: The aim of this study was to evaluate the expression of level COX-2 protein in patients with colorectal carcinoma in order to better understand the pathophysiology and behavior of inflammatory factors in this disease. Subjects and Methods: In this cross-sectional descriptive study, tissue paraffin blocks of patients referring to Ahvaz Imam Khomeini teaching hospital with pathological diagnosis of Colorectal Cancer were evaluated. Clinical and demographic data of patients were extracted from hospital records. Anti-COX-2 monoclonal antibody was used for immunohistochemical staining. Results: In this study, 31 patients with Colorectal Cancer (mean age 65. 1 (range 33 to 89)) were evaluated. Most tumors had grade G2 (54. 8%). Tumor Stage pt3 was also seen in more than half of cases. Lymph node involvement was observed in 29% of cases. The mean staining area was 34. 6% (range 2 to 78%). More than half of the patients showed moderate marker expression and 6. 5% had a strong positive reaction. However, 16. 1% of patients were negative for COX-2 marker. No significant correlation bewteen the stage, grade and lymph node involvement with COX-2 expression status was found. Conclusion: The findings of this study indicate that more than 70% of colorectal malignant tissues express COX-2 marker. However, COX-2 marker expression had no significant association with pathologic variables such as Tumor Grade, stage and lymph nodes involvement.

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References

The role of cyclooxygenase-2 in colorectal carcinogenesis

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APA: Copy

SHABANI, MOHSEN, & Kheradmand, Parvin. (2020). Evaluation of COX-2 Expression in Colorectal Carcinoma in Patients Undergoing Colectomy in Ahvaz Imam Khomeini Hospital. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 19(2 ), 177-186. SID. https://sid.ir/paper/388548/en

Vancouver: Copy

SHABANI MOHSEN, Kheradmand Parvin. Evaluation of COX-2 Expression in Colorectal Carcinoma in Patients Undergoing Colectomy in Ahvaz Imam Khomeini Hospital. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2020;19(2 ):177-186. Available from: https://sid.ir/paper/388548/en

IEEE: Copy

MOHSEN SHABANI, and Parvin Kheradmand, “Evaluation of COX-2 Expression in Colorectal Carcinoma in Patients Undergoing Colectomy in Ahvaz Imam Khomeini Hospital,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 19, no. 2 , pp. 177–186, 2020, [Online]. Available: https://sid.ir/paper/388548/en

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