COMPARISON OF THE EFFECTS OF VITAMIN E AND NICOTINIC ACID ON SERUM LIPIDS AND APOPROTEINS OF HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS

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TABIBI H.; SIASI F.; MAHDAVI M.; JALALI M.; ESHRAGHIAN M.R.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2005 | Volume:62 | Issue:12 Page(s): 994-1007

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Title

COMPARISON OF THE EFFECTS OF VITAMIN E AND NICOTINIC ACID ON SERUM LIPIDS AND APOPROTEINS OF HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS

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Keywords

VITAMIN E NICOTINIC ACIDQ4

HEMODIALYSISQ4

LIPIDSQ4

APOPROTEINSQ4

Abstract

Background: Oxidative stress and lipid abnormalities are the two major risk factors for atherosclerosis in hemodialyzed patients. Vitamin E ,as an antioxidant, can reduce oxidative stress in these patients but its effects on serum lipid abnormalities are not well known. Therefore, the present study was desinged to compare the effects of vitamin E with those of nicotinic acid ,as a drug, on serum LIPIDS and APOPROTEINS in hypertriglyceridemic hemodialyzed patients. Material and methods: The study was a double-blind randomized clinical trial. Thirty-nine hemodialyzed patients with fasting triglyceride range of 230 to 500 mg/dl were randomly assigned to vitamin E (600mg/d) , nicotinic acid (500mg/d) and placebo groups. All patients received their supplements for 13 weeks. The blood samples were collected after a 12 to 14-hour fast at the beginning of the study and at the end of sixth and thirteenth weeks and then serum LIPIDS and APOPROTEINS were measured.Results: During the study, mean serum triglyceride level was significantly reduced in the vitamin E group compared to the placebo group (P<0.05).Mean serum HDL-C level was significantly increased in the nicotinic acid group when compared to the placebo group (P<0.05) but LDL-C/HDL-C ratio was significantly decreased (P<0.01). There were no significant differences among mean changes of serum total cholesterol, LDL-C , apoAI , apoB100 and Lp (a) of three groups.Conclusion: It is concluded that vitamin E is effective in reducing triglyceride concentration in hypertriglyceridemic hemodialyzed patients but it appears that combined use of vitamin E and nicotinic acid is more effective in regulating lipid abnormalities in these patients.

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APA: Copy

TABIBI, H., SIASI, F., MAHDAVI, M., JALALI, M., & ESHRAGHIAN, M.R.. (2005). COMPARISON OF THE EFFECTS OF VITAMIN E AND NICOTINIC ACID ON SERUM LIPIDS AND APOPROTEINS OF HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(12), 994-1007. SID. https://sid.ir/paper/39535/en

Vancouver: Copy

TABIBI H., SIASI F., MAHDAVI M., JALALI M., ESHRAGHIAN M.R.. COMPARISON OF THE EFFECTS OF VITAMIN E AND NICOTINIC ACID ON SERUM LIPIDS AND APOPROTEINS OF HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;62(12):994-1007. Available from: https://sid.ir/paper/39535/en

IEEE: Copy

H. TABIBI, F. SIASI, M. MAHDAVI, M. JALALI, and M.R. ESHRAGHIAN, “COMPARISON OF THE EFFECTS OF VITAMIN E AND NICOTINIC ACID ON SERUM LIPIDS AND APOPROTEINS OF HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 12, pp. 994–1007, 2005, [Online]. Available: https://sid.ir/paper/39535/en

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