PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASES AMONG STRAINS OF PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN PATIENTS

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MIRSALEHIAN A.; FEYZABADI M.M.; AKBARI NAKHJAVANI F.; JABAL AMELI FERESHTEH; GOLI H.R.

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Journal: Tehran University Medical Journal Year:2008 | Volume:66 | Issue:5 Page(s): 333-337

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Title

PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASES AMONG STRAINS OF PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN PATIENTS

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Keywords

EXTENDED SPECTRUMQ3

BETA LACTAMASEQ3

ANTIMICROBIAL SUSCEPTIBILITY TESTQ3

PCRQ3

PSEUDOMONAS AERUGINOSAQ3

Abstract

Background: The resistance of PSEUDOMONAS AERUGINOSA strains to broad spectrum cephalosporins may be mediated by EXTENDED SPECTRUM b-lactamases (ESBLs). These enzymes are encoded by different genes located either on chromosome or plasmids. In this study, we determined the antimicrobial resistance patterns of P. aeruginosa isolates and screened for ESBL production.Methods: After isolation from burn patients in Tehran Hospital, identification of P. aeruginosa isolates were assessed using biochemical tests. We then performed disk agar diffusion (DAD) according to CLSI guidelines to determine the pattern of antimicrobial resistance. The frequency of ESBLs and prevalence of the OXA-10 and PER-1 genes were determined with combined disk and polymerase chain reaction (PCR) methods, respectively.Results: One hundred strains of P. aeruginosa were isolated. The resistance of these strains to cephpodoxime, aztreonam, ciprofloxacin, ofloxacin, ceftazidime, cefepime, imipenem, meropenem, cefotaxime, levofloxacin, piperacilin- tazobactam and ceftriaxon was 100%, 90%, 83%, 92%, 85%, 88%, 63%, 66%, 98%, 89%, 70% and 91%, respectively. Of these, 40 strains (40%) were ESBL positive, 29 strains (29%) were OXA-10 positive and 18 strains (18%) were PER-1 positive.Conclusion: Our results confirm the need for proper antimicrobial therapy in burn hospitals, considering the resistance pattern and frequency of strains producing ESBLs and the presence of the OXA-10 and PER-1 genes. Since an increase in the prevalence of ESBL in P. aeruginosa strains might lead to the transfer of these ESBL genes to other gram-negative bacteria, we recommend the use of appropriate drugs, especially cephalosporins, in burn hospitals.

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APA: Copy

MIRSALEHIAN, A., FEYZABADI, M.M., AKBARI NAKHJAVANI, F., JABAL AMELI, FERESHTEH, & GOLI, H.R.. (2008). PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASES AMONG STRAINS OF PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(5), 333-337. SID. https://sid.ir/paper/397825/en

Vancouver: Copy

MIRSALEHIAN A., FEYZABADI M.M., AKBARI NAKHJAVANI F., JABAL AMELI FERESHTEH, GOLI H.R.. PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASES AMONG STRAINS OF PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2008;66(5):333-337. Available from: https://sid.ir/paper/397825/en

IEEE: Copy

A. MIRSALEHIAN, M.M. FEYZABADI, F. AKBARI NAKHJAVANI, FERESHTEH JABAL AMELI, and H.R. GOLI, “PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASES AMONG STRAINS OF PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN PATIENTS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 5, pp. 333–337, 2008, [Online]. Available: https://sid.ir/paper/397825/en

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