Effect of Salvia Officinalis Extract (Sage) on the Toxicity and Oxidative Stress of Deltamethrin in Kidneys of the Rats

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Samiei Sajjad; KHADEM MONIREH; Pourbabaki reza; Amirkhanlou Fatemeh; Shahtaher Seyed Jamaleddin

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Journal: JOURNAL OF OCCUPATIONAL HYGIENE ENGINEERING Year:2020 | Volume:7 | Issue:3 Page(s): 36-46

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Title

Effect of Salvia Officinalis Extract (Sage) on the Toxicity and Oxidative Stress of Deltamethrin in Kidneys of the Rats

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Keywords

AntioxidantQ1

DeltamethrinQ1

KidneyQ1

Oxidative StressQ1

RatQ1

Salvia Officinalis Extract (Sage)Q1

Abstract

Background and Objective: Pyrethroids (i. e., Deltamethrin) are one of the most common insecticides that are used extensively in agriculture to control the insects. Oxidative Stress is one of the main mechanisms of pesticides, including Deltamethrin, in developing toxicity. Many plants contain high levels of Antioxidants that can play a role in absorbing and neutralizing free radicals. The current study aimed to assess the oxidative and protective role of Salvia officinalis extract (Sage) in alleviating the detrimental effect of Deltamethrin and the induced Oxidative Stress on the Kidneys of the male Rats. Materials and Methods: In total, 30 Wistar Rats were randomly divided into five groups of six animals per group. Group 1 was considered the control group, and group II received Deltamethrin (15mg/kg). Moreover, group III received Deltamethrin and Salvia officinalis extract (100mg/kg), and group IV received Deltamethrin (15mg/kg) and Salvia officinalis extract (200mg/kg). Group V received Salvia officinalis extract (100mg/kg). The treatment was extended for one month, and subsequently, the Kidney tissues of all Rats were evaluated to assess the malondialdehyde and glutathione peroxidase levels using appropriate assessment kits. It is worth mentioning that histopathological changes were also investigated in this study. Results: The results showed that Salvia extract significantly reduced the toxic effects of Deltamethrin in the Kidneys of the Rats. Moreover, Salvia extract significantly reduced malondialdehyde levels and improved glutathione peroxidase activity. The results of Kidney tissue pathology also confirmed Salvia’ s protective effect against Deltamethrin. Conclusion: The protective effect of Salvia extract can be due to phenolic compounds and Antioxidant activities, which can be used as an effective factor in the prevention and improvement of the toxic effects of Deltamethrin.

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APA: Copy

Samiei, Sajjad, KHADEM, MONIREH, Pourbabaki, reza, Amirkhanlou, Fatemeh, & Shahtaher, Seyed Jamaleddin. (2020). Effect of Salvia Officinalis Extract (Sage) on the Toxicity and Oxidative Stress of Deltamethrin in Kidneys of the Rats. JOURNAL OF OCCUPATIONAL HYGIENE ENGINEERING, 7(3 ), 36-46. SID. https://sid.ir/paper/401052/en

Vancouver: Copy

Samiei Sajjad, KHADEM MONIREH, Pourbabaki reza, Amirkhanlou Fatemeh, Shahtaher Seyed Jamaleddin. Effect of Salvia Officinalis Extract (Sage) on the Toxicity and Oxidative Stress of Deltamethrin in Kidneys of the Rats. JOURNAL OF OCCUPATIONAL HYGIENE ENGINEERING[Internet]. 2020;7(3 ):36-46. Available from: https://sid.ir/paper/401052/en

IEEE: Copy

Sajjad Samiei, MONIREH KHADEM, reza Pourbabaki, Fatemeh Amirkhanlou, and Seyed Jamaleddin Shahtaher, “Effect of Salvia Officinalis Extract (Sage) on the Toxicity and Oxidative Stress of Deltamethrin in Kidneys of the Rats,” JOURNAL OF OCCUPATIONAL HYGIENE ENGINEERING, vol. 7, no. 3 , pp. 36–46, 2020, [Online]. Available: https://sid.ir/paper/401052/en

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