EFFECT OF TIME COURSES OF TREADMILL TRAINING ON TISSUE TOXICITY INDUCED BY DIFFERENT DOSES OF DOXORUBICIN IN MULTIPLE ORGANS

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SADAT HOSSEINI SEYED KAMAL; DABIDI ROSHAN VALIOLLAH; SHOJAEI SHAHROKHABADI MOHADESEH

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Journal: Razi Journal of Medical Sciences Year:2017 | Volume:23 | Issue:151 Page(s): 31-42

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Title

EFFECT OF TIME COURSES OF TREADMILL TRAINING ON TISSUE TOXICITY INDUCED BY DIFFERENT DOSES OF DOXORUBICIN IN MULTIPLE ORGANS

Author(s)

SADAT HOSSEINI SEYED KAMAL | DABIDI ROSHAN VALIOLLAH | SHOJAEI SHAHROKHABADI MOHADESEH | Issue Writer Certificate

Keywords

DOXORUBICINQ1

AEROBIC EXERCISEQ1

TISSUE TOXICITYQ1

Abstract

Background: The aim of this study was to investigate the pretreatment effects of time courses of training and different doses of medication in multiple organs (liver and heart) of rats treated with DOXORUBICIN (DOX).Methods: in this experimental study, Seventy-two Wistar male rats were randomly assigned to control and training groups with three subgroups: DOX 10mg/kg, DOX 20mg/kg and saline. The training protocol included treadmill running progressively between 25 to 54 min/day and 15 to 20 m/min, 5 days/week for 6 and 3 weeks. DOX and saline injection was performed 24 hr after the last exercise session, and tissue collection was done 24 hr after the injections.Results: Acute administration of DOX 20mg/kg, caused a significant increase in Heat Shock Protein (HSP) and significant decrease in Catalase (CAT) and difference between two tissue (liver and heart) was significant. Six and three weeks training before DOX 20 mg/kg and DOX 10 mg/kg administration led to insignificant and significant increase in HSP, in the liver and heart, respectively. In addition, six weeks training before administration of different doses of DOX, led to significant increase in CAT in both tissue. Also, there was significant difference between two tissues after six and three weeks training.Conclusion: The results of the present study represent that regular AEROBIC EXERCISE, by increasing protective and antioxidant markers, can be prescribed as a pretreatment strategy against DOX-induced TISSUE TOXICITY (liver and heart).

Cites

The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats

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APA: Copy

SADAT HOSSEINI, SEYED KAMAL, DABIDI ROSHAN, VALIOLLAH, & SHOJAEI SHAHROKHABADI, MOHADESEH. (2017). EFFECT OF TIME COURSES OF TREADMILL TRAINING ON TISSUE TOXICITY INDUCED BY DIFFERENT DOSES OF DOXORUBICIN IN MULTIPLE ORGANS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 23(151), 31-42. SID. https://sid.ir/paper/10555/en

Vancouver: Copy

SADAT HOSSEINI SEYED KAMAL, DABIDI ROSHAN VALIOLLAH, SHOJAEI SHAHROKHABADI MOHADESEH. EFFECT OF TIME COURSES OF TREADMILL TRAINING ON TISSUE TOXICITY INDUCED BY DIFFERENT DOSES OF DOXORUBICIN IN MULTIPLE ORGANS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2017;23(151):31-42. Available from: https://sid.ir/paper/10555/en

IEEE: Copy

SEYED KAMAL SADAT HOSSEINI, VALIOLLAH DABIDI ROSHAN, and MOHADESEH SHOJAEI SHAHROKHABADI, “EFFECT OF TIME COURSES OF TREADMILL TRAINING ON TISSUE TOXICITY INDUCED BY DIFFERENT DOSES OF DOXORUBICIN IN MULTIPLE ORGANS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 23, no. 151, pp. 31–42, 2017, [Online]. Available: https://sid.ir/paper/10555/en

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