The effect of electrical low-frequency stimulation on balance and locomotor activity in adult male rats during epileptogenesis of dorsal hippocampal

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MOGHADDASI R.; Moazedi Moazedi; GHOTBEDDIN Z.; AKHOND M.R.

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Journal: Feyz Medical Sciences Journal Year:2019 | Volume:22 | Issue:6 Page(s): 538-546

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Information Journal Paper

Title

The effect of electrical low-frequency stimulation on balance and locomotor activity in adult male rats during epileptogenesis of dorsal hippocampal

Author(s)

MOGHADDASI R. | Moazedi Moazedi | GHOTBEDDIN Z. | AKHOND M.R. | Issue Writer Certificate

Keywords

KindlingQ2

Low-frequency electrical stimulationQ1

BalanceQ2

Motor activityQ2

RotarodQ2

Open fieldQ1

RatQ2

Abstract

Background: Epilepsy is the third world neurological disorder. Epileptic focus causes motor impairment by sending projections to different areas of the brain such as areas which are related to movement control. Regarding the inhibitory effect of Low-frequency electrical stimulation (LFS) on seizure wave's transmission, this study aimed at examining the effect of LFS during the epileptogenesis of dorsal hippocampal on Balance and locoMotor activity in adult male Rats using the Kindling method. Materials and Methods: Fifty Rats were randomly divided into 5 groups: Control, Sham, Kindled, LFS and KLFS. Animals in the kindled group were stimulated rapidly by daily stimulation of dorsal hippocampus (1 ms pulse duRation at 50Hz for 3 seconds). Animals in the sham and control groups did not receive any stimulation. In the LFS groups, four LFS packages at a frequency of 1 Hz were applied daily. At the end of stimulation, Motor activity and Balance were assessed by open-field and Rotarod tests. Results: Frequency of rearing and grooming in the Kindled group significantly increased compared to the control group (P<0. 05). Balance in the Kindled group was significantly decreased (P<0. 05). LFS induction during hippocampal Kindling did not show any significant difference in any of the mentioned parameters with the control group. Conclusion: In summary, applying Low-frequency electrical stimulation during hippocampal Kindling can reduce the Motor activity and improve Balance.

Cites

Increasing the Effectiveness of Carbamazepine by Low Frequency Electrical Stimulation During CA1 Hippocampal Kindling on Seizure Scales in Adult Male Rats: An Experimental Study

References

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APA: Copy

MOGHADDASI, R., Moazedi, Moazedi, GHOTBEDDIN, Z., & AKHOND, M.R.. (2019). The effect of electrical low-frequency stimulation on balance and locomotor activity in adult male rats during epileptogenesis of dorsal hippocampal. FEYZ, 22(6 ), 538-546. SID. https://sid.ir/paper/40447/en

Vancouver: Copy

MOGHADDASI R., Moazedi Moazedi, GHOTBEDDIN Z., AKHOND M.R.. The effect of electrical low-frequency stimulation on balance and locomotor activity in adult male rats during epileptogenesis of dorsal hippocampal. FEYZ[Internet]. 2019;22(6 ):538-546. Available from: https://sid.ir/paper/40447/en

IEEE: Copy

R. MOGHADDASI, Moazedi Moazedi, Z. GHOTBEDDIN, and M.R. AKHOND, “The effect of electrical low-frequency stimulation on balance and locomotor activity in adult male rats during epileptogenesis of dorsal hippocampal,” FEYZ, vol. 22, no. 6 , pp. 538–546, 2019, [Online]. Available: https://sid.ir/paper/40447/en

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