INVOLVEMENT OF DORSAL HIPPOCAMPAL BETA-1 NORADRENERGIC RECEPTORS IN MEMORY RETRIEVAL OF RATS

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FATHINIA K.; KHAJEHPOUR L.; MOAZEDI A.A.; BEMANI LIRGESHASI S.

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Journal: Feyz Medical Sciences Journal Year:2014 | Volume:7 | Issue:6 Page(s): 582-589

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Title

INVOLVEMENT OF DORSAL HIPPOCAMPAL BETA-1 NORADRENERGIC RECEPTORS IN MEMORY RETRIEVAL OF RATS

Author(s)

FATHINIA K. | KHAJEHPOUR L. | MOAZEDI A.A. | BEMANI LIRGESHASI S. | Issue Writer Certificate

Keywords

BETA-1 ADRENERGIC RECEPTORSQ2

HIPPOCAMPUSQ2

MEMORYQ2

Abstract

Background: Central beta-noradrenergic system plays an important role in the learning and MEMORY processes. Dorsal HIPPOCAMPUS also has an overlapped distribution of beta-noradrenergic receptors. The aim of this study was to evaluate the possible role of the dorsal hippocampal beta-1 noradrenergic receptors in MEMORY retrieval using a passive avoidance learning task.Materials and Methods: This experimental study was performed on adult male Wistar rats (weight, 230±20 gr). After anaesthetizing, the rats were cannulated into dorsal HIPPOCAMPUS using the stereotaxic surgery. After one week, passive avoidance MEMORY was studied in two phases: training and testing with a 24h interval. The step-through latency to enter dark compartment and the time spent in this compartment was recorded for the evaluation of MEMORY. All animals received drugs or saline, as intra- dorsal hippocampal microinjection, 30 min before testing.Results: Pre-testing administration of dobutamine (1 mg/rat), a beta-1 noradrenergic receptor agonist, potentiated passive avoidance MEMORY retrieval, while pre-testing injection of betaxolol (0.5 mg/rat), a beta-1 noradrenergic receptor antagonist, inhibited passive avoidance MEMORY retrieval. Also, the injection of ineffective and low doses of betaxolol (0.125 and 0.25 mg/rat) inhibited the effect of dobutamine on the MEMORY retrieval.Conclusion: It seems that beta-1 noradrenergic receptors of the dorsal HIPPOCAMPUS may mediate MEMORY retrieval in a passive avoidance learning model.

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APA: Copy

FATHINIA, K., KHAJEHPOUR, L., MOAZEDI, A.A., & BEMANI LIRGESHASI, S.. (2014). INVOLVEMENT OF DORSAL HIPPOCAMPAL BETA-1 NORADRENERGIC RECEPTORS IN MEMORY RETRIEVAL OF RATS. FEYZ, 7(6), 582-589. SID. https://sid.ir/paper/40471/en

Vancouver: Copy

FATHINIA K., KHAJEHPOUR L., MOAZEDI A.A., BEMANI LIRGESHASI S.. INVOLVEMENT OF DORSAL HIPPOCAMPAL BETA-1 NORADRENERGIC RECEPTORS IN MEMORY RETRIEVAL OF RATS. FEYZ[Internet]. 2014;7(6):582-589. Available from: https://sid.ir/paper/40471/en

IEEE: Copy

K. FATHINIA, L. KHAJEHPOUR, A.A. MOAZEDI, and S. BEMANI LIRGESHASI, “INVOLVEMENT OF DORSAL HIPPOCAMPAL BETA-1 NORADRENERGIC RECEPTORS IN MEMORY RETRIEVAL OF RATS,” FEYZ, vol. 7, no. 6, pp. 582–589, 2014, [Online]. Available: https://sid.ir/paper/40471/en

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