INVOLVEMENT OF DORSAL HIPPOCAMPAL α1-ADRENERGIC RECEPTORS IN THE EFFECT OF WIN55, 212-2 ON MEMORY RETRIEVAL IN INHIBITORY AVOIDANCE TASK

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MOSHFEGH A.; BABAEI P.; PIRI M.; ORYAN SH.; SOLTANI B.; ZARRINDAST M.

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Journal: PHARMACEUTICAL SCIENCES Year:2010 | Volume:16 | Issue:2 Page(s): 99-106

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Title

INVOLVEMENT OF DORSAL HIPPOCAMPAL α1-ADRENERGIC RECEPTORS IN THE EFFECT OF WIN55, 212-2 ON MEMORY RETRIEVAL IN INHIBITORY AVOIDANCE TASK

Author(s)

Keywords

WIN55Q1

212-2Q1

PHENYLEPHRINEQ1

PRAZOSINQ1

DORSAL HIPPOCAMPUSQ1

STATE DEPENDENT LEARNINGQ1

Abstract

Objective: The present study evaluated the possible role of a1-adrenergic receptors of the DORSAL HIPPOCAMPUS on WIN55, 212-2 induced amnesia and WIN55, 212-2 state-dependent memory in adult male Wistar rats.Methods: In this study PHENYLEPHRINE as agonist and PRAZOSIN as antagonist of a1-adrenergic receptor, WIN55, 212-2 as agonist of cannabinoid receptor was used. The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the DORSAL HIPPOCAMPUS, trained in a step-down type inhibitory avoidance task, and tested 24 h after training to measure step-down latency.Results: post-training intra-CA1 administration of WIN55, 212-2 (0.25 and 0.5 mg/rat) impaired the memory retrieval. Amnesia produced by post-training WIN55, 212-2 (0.5 mg/rat) was reversed by pre-test administration of the same dose of WIN55, 212-2 that is due to a state-dependent effect. Pre-test intra-CA1 injection of PHENYLEPHRINE (0.5 and 0.75 mg/rat) improved post-training WIN55, 212-2 (0.5 mg/rat)-induced retrieval impairment. On the other hand, pre-test injection of PRAZOSIN prevented the restoration of memory by pre-test WIN55, 212-2. It is important to note that pre-test intra-CA1 administration of the same doses of PRAZOSIN or PHENYLEPHRINE, alone did not affect memory retrieval.Conclusion: These results suggest that a1-adrenergic receptors of the dorsal hippocampal CA1 regions may play an important role in WIN55, 212-2 state-dependent memory.

Cites

THE EFFECT OF D2 RECEPTOR AGONIST INJECTION IN THE NUCLEUS ACCUMBENS ON RESTORATION OF MORPHINE INDUCED AMNESIA BY NICOTINE IN MALE RATS

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APA: Copy

MOSHFEGH, A., BABAEI, P., PIRI, M., ORYAN, SH., SOLTANI, B., & ZARRINDAST, M.. (2010). INVOLVEMENT OF DORSAL HIPPOCAMPAL α1-ADRENERGIC RECEPTORS IN THE EFFECT OF WIN55, 212-2 ON MEMORY RETRIEVAL IN INHIBITORY AVOIDANCE TASK. PHARMACEUTICAL SCIENCES, 16(2), 99-106. SID. https://sid.ir/paper/48530/en

Vancouver: Copy

MOSHFEGH A., BABAEI P., PIRI M., ORYAN SH., SOLTANI B., ZARRINDAST M.. INVOLVEMENT OF DORSAL HIPPOCAMPAL α1-ADRENERGIC RECEPTORS IN THE EFFECT OF WIN55, 212-2 ON MEMORY RETRIEVAL IN INHIBITORY AVOIDANCE TASK. PHARMACEUTICAL SCIENCES[Internet]. 2010;16(2):99-106. Available from: https://sid.ir/paper/48530/en

IEEE: Copy

A. MOSHFEGH, P. BABAEI, M. PIRI, SH. ORYAN, B. SOLTANI, and M. ZARRINDAST, “INVOLVEMENT OF DORSAL HIPPOCAMPAL α1-ADRENERGIC RECEPTORS IN THE EFFECT OF WIN55, 212-2 ON MEMORY RETRIEVAL IN INHIBITORY AVOIDANCE TASK,” PHARMACEUTICAL SCIENCES, vol. 16, no. 2, pp. 99–106, 2010, [Online]. Available: https://sid.ir/paper/48530/en

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