MOLECULAR IDENTIFICATION OF CTX-M, TEM AND SHV β-LACTAMASES IN KLEBSIELLA PNEUMONIAEISOLATED FROM RESPIRATORY SYSTEM OF PATIENTS IN THE ICU OF EDUCATIONAL HOSPITALS IN TEHRAN

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SOROUSH Z.; GHANE M.

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Journal Paper

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Journal: Feyz Medical Sciences Journal Year:2017 | Volume:21 | Issue:3 Page(s): 232-239

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Title

MOLECULAR IDENTIFICATION OF CTX-M, TEM AND SHV β-LACTAMASES IN KLEBSIELLA PNEUMONIAEISOLATED FROM RESPIRATORY SYSTEM OF PATIENTS IN THE ICU OF EDUCATIONAL HOSPITALS IN TEHRAN

Author(s)

SOROUSH Z. | GHANE M. | Issue Writer Certificate

Keywords

KLEBSIELLA PNEUMONIAEQ1

ANTI-BACTERIAL AGENTSQ2

INTENSIVE CARE UNITSQ2

BETALACTAMASESQ2

MULTIPLEX POLYMERASE CHAIN REACTIONQ1

Abstract

Background: Extended-spectrum beta-lactamases (ESBL) producing isolates of KLEBSIELLA PNEUMONIAEwhich have been increased in the hospitals were resulting in limitation of therapeutic options. The aims of this study were to evaluate the antibiotic susceptibility pattern and presence of ESBL genes in clinical isolates ofKLEBSIELLA PNEUMONIAE from patients admitted to the INTENSIVE CARE UNITS (ICUs).Materials and Methods: In this descriptive cross-sectional study, a total of 65 KLEBSIELLA PNEUMONIAEstrains were isolated from ICUs of educational hospitals in Tehran. Identification was performed using biochemical tests and the antimicrobial susceptibility was performed as recommended by the Clinical and Laboratory Standards Institute (CLSI). Molecular analysis of the ESBL genes was performed by Multiplex PCR (M-PCR).Results: Most of the isolates were resistant to Cotrimoxazole (72.3%), Gentamicin (67.7%) and Ampicillin (69.2%) and the highest susceptibility was seen for Ciprofloxacin (50.8%) Tetracycline (49.2%), Imipenem (46.3%) and Ceftriaxone (43.1%). Among the ESBLproducing genes, bla CTX-M (55.3 %) was the most prevalent, followed by bla TEM (41.5 %) andbla SHV (10.7 %). The results showed that 1.5 % of the isolates had concurrently blaTEM/ bla SHV and bla SHV/ bla CTX-M genes and 21.6% of isolates the bla TEM/ blaCTX-M genes.Conclusion: These findings reveal the high prevalence of multi drug resistant and ESBLproducing KLEBSIELLA PNEUMONIAEin patients hospitalized in ICUs and emphasize the need for appropriate infection control policies.

Cites

Identification and sequencing of bla CTX-M genes in clinical isolates of Klebsiella pneumoniae isolated from Milad hospital

References

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APA: Copy

SOROUSH, Z., & GHANE, M.. (2017). MOLECULAR IDENTIFICATION OF CTX-M, TEM AND SHV β-LACTAMASES IN KLEBSIELLA PNEUMONIAEISOLATED FROM RESPIRATORY SYSTEM OF PATIENTS IN THE ICU OF EDUCATIONAL HOSPITALS IN TEHRAN. FEYZ, 21(3), 232-239. SID. https://sid.ir/paper/40532/en

Vancouver: Copy

SOROUSH Z., GHANE M.. MOLECULAR IDENTIFICATION OF CTX-M, TEM AND SHV β-LACTAMASES IN KLEBSIELLA PNEUMONIAEISOLATED FROM RESPIRATORY SYSTEM OF PATIENTS IN THE ICU OF EDUCATIONAL HOSPITALS IN TEHRAN. FEYZ[Internet]. 2017;21(3):232-239. Available from: https://sid.ir/paper/40532/en

IEEE: Copy

Z. SOROUSH, and M. GHANE, “MOLECULAR IDENTIFICATION OF CTX-M, TEM AND SHV β-LACTAMASES IN KLEBSIELLA PNEUMONIAEISOLATED FROM RESPIRATORY SYSTEM OF PATIENTS IN THE ICU OF EDUCATIONAL HOSPITALS IN TEHRAN,” FEYZ, vol. 21, no. 3, pp. 232–239, 2017, [Online]. Available: https://sid.ir/paper/40532/en

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