PERSISTENCE OF ANTI-HBS ANTIBODY AND IMMUNE MEMORY TO HEPATITIS B VACCINE, 18 YEARS AFTER INFANTILE VACCINATION IN STUDENTS OF TEHRAN UNIVERSITY

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NORROZI M.; AZAMI A.; SARRAF NEDUAD A.; CHITSAZ H.; RAHMATI N.

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Journal: Research in Medicine Year:2016 | Volume:40 | Issue:1 Page(s): 36-41

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Title

PERSISTENCE OF ANTI-HBS ANTIBODY AND IMMUNE MEMORY TO HEPATITIS B VACCINE, 18 YEARS AFTER INFANTILE VACCINATION IN STUDENTS OF TEHRAN UNIVERSITY

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Keywords

INFANTILE HBV VACCINATIONQ1

ANTI-HBS ANTIBODYQ1

ANAMNESTIC RESPONSEQ1

LONG-TERMQ1

Abstract

Background: Although several studies confirm LONG-TERM serum protection and immune memory of infantile-hepatitis B vaccination, but the duration and time of the loss of immunity is still unknown. We assessed antibody persistence and immunological memory to hepatitis B, 18 years after vaccination during infancy in freshman students of Tehran University (2012-2013).Material and Methods: This study was conducted on 395 students with a history of 3 times infant HB vaccination (first week, 1-3 months, 6-9 months, 10 μg recombinant HBV vaccine) 18 years ago (in accordance with the national vaccination program). Antibody against HBs Ag (anti-HBs) was measured and participants who had not a serum protection (anti-HBs<10 mIu/mL) were given a booster dose (20μg recombinant HBV vaccine) and the immune response was evaluated 10 to 14 days after injection.Increased antibody titer (³10 mIu/mL) was considered as an enhanced response (anamnestic response); which is suggestive for immunological memory.Results: Anti-HBs seropositivity rate was 79.2% (n=313). The number of seronegative participants was 82 (20.8%) that 40 of them were not willing to cooperate and the remaining 42 received a booster dose and ANAMNESTIC RESPONSE observed in 92.9% (n=39). After the booster dose geometric mean (GMCs) and range of anti-HBs antibodies were 216.8 and 1084.3 respectively (n=42). The mean antibody concentration was significantly different after the boost than before (3.07±1.37 vs.517.97±435.75, p=0.000).Conclusion: Although the findings of this study show that 79.2% of participants had serum protection and immunological memory of infantile HBV immunization retained for 18 years in 92.9% of seronegative participants who received a booster dose, but still the time of deterioration of immunization is unclear.Therefore, we recommend that further studies be conducted with larger sample size in older people in different regions of the country.

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APA: Copy

NORROZI, M., AZAMI, A., SARRAF NEDUAD, A., CHITSAZ, H., & RAHMATI, N.. (2016). PERSISTENCE OF ANTI-HBS ANTIBODY AND IMMUNE MEMORY TO HEPATITIS B VACCINE, 18 YEARS AFTER INFANTILE VACCINATION IN STUDENTS OF TEHRAN UNIVERSITY. PAJOUHESH DAR PEZESHKI, 40(1 ), 36-41. SID. https://sid.ir/paper/41813/en

Vancouver: Copy

NORROZI M., AZAMI A., SARRAF NEDUAD A., CHITSAZ H., RAHMATI N.. PERSISTENCE OF ANTI-HBS ANTIBODY AND IMMUNE MEMORY TO HEPATITIS B VACCINE, 18 YEARS AFTER INFANTILE VACCINATION IN STUDENTS OF TEHRAN UNIVERSITY. PAJOUHESH DAR PEZESHKI[Internet]. 2016;40(1 ):36-41. Available from: https://sid.ir/paper/41813/en

IEEE: Copy

M. NORROZI, A. AZAMI, A. SARRAF NEDUAD, H. CHITSAZ, and N. RAHMATI, “PERSISTENCE OF ANTI-HBS ANTIBODY AND IMMUNE MEMORY TO HEPATITIS B VACCINE, 18 YEARS AFTER INFANTILE VACCINATION IN STUDENTS OF TEHRAN UNIVERSITY,” PAJOUHESH DAR PEZESHKI, vol. 40, no. 1 , pp. 36–41, 2016, [Online]. Available: https://sid.ir/paper/41813/en

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