DOWN-REGULATION OF MIR-199B IN PATIENTS WITH ACUTE MYELOID LEUKEMIA

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AMIRKHANI MANSOUREH; ONSORY KHADIJEH

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Journal: Research in Medicine Year:2018 | Volume:42 | Issue:2 Page(s): 110-115

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Title

DOWN-REGULATION OF MIR-199B IN PATIENTS WITH ACUTE MYELOID LEUKEMIA

Author(s)

AMIRKHANI MANSOUREH | ONSORY KHADIJEH | Issue Writer Certificate

Keywords

ACUTE MYELOID LEUKEMIAQ2

MIR-199BQ1

REAL TIME PCRQ1

Abstract

Background: ACUTE MYELOID LEUKEMIA (AML) is the second most prevalent blood cancer in Iran and the fifth prevalent cancer in the world, which involves 8% of all the cancers. MicroRNAs are a class of small non-coding RNAs which have recently been shown to play a crucial role in major cellular processes such as development and differentiation, which can change the genes regulation that may lead to cancer development.So far, the MIR-199B expression has been studied in many types of solid cancers; therefore, the purpose of the present study was to determine the MIR-199B expression in AML. type of blood cancer.Materials and Methods: In the present case-control study, miR199b expression was investigated in 30 patients with AML admitted to Mirzakochak khan Jangali Hospital, in 2016, using REAL TIME PCR and the results were compared with those of the same number of healthy individuals as control. Statistical analyses were performed using SPSS (version 19), Graphpad, and Prism 6 running t-tests. P values<0.05 were considered as significant.Results: There was a statistically significant reduction in miR199b expression in patients as compared with control group (P=0.0001) while no correlation was observed between patients’ age (P=0.545) and sex (P=0.704) with MIR-199B down-regulation among the studied population.Conclusion: MIR-199B, as a tumor suppressor, showed a reduction in its expression. Therefore, evaluation of expression of that can be used as a diagnostic agent and also a prognostic factor in patients with AML.

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APA: Copy

AMIRKHANI, MANSOUREH, & ONSORY, KHADIJEH. (2018). DOWN-REGULATION OF MIR-199B IN PATIENTS WITH ACUTE MYELOID LEUKEMIA. PAJOUHESH DAR PEZESHKI, 42(2 ), 110-115. SID. https://sid.ir/paper/41972/en

Vancouver: Copy

AMIRKHANI MANSOUREH, ONSORY KHADIJEH. DOWN-REGULATION OF MIR-199B IN PATIENTS WITH ACUTE MYELOID LEUKEMIA. PAJOUHESH DAR PEZESHKI[Internet]. 2018;42(2 ):110-115. Available from: https://sid.ir/paper/41972/en

IEEE: Copy

MANSOUREH AMIRKHANI, and KHADIJEH ONSORY, “DOWN-REGULATION OF MIR-199B IN PATIENTS WITH ACUTE MYELOID LEUKEMIA,” PAJOUHESH DAR PEZESHKI, vol. 42, no. 2 , pp. 110–115, 2018, [Online]. Available: https://sid.ir/paper/41972/en

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