EFFECTS OF HARMANE, NORHARMANE AND HARMINE ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN CHICK

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FARZIN D.; SALIMI E.

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Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2009 | Volume:19 | Issue:70 Page(s): 1-8

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Title

EFFECTS OF HARMANE, NORHARMANE AND HARMINE ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN CHICK

Author(s)

FARZIN D. | SALIMI E. | Issue Writer Certificate

Keywords

STEREOTYPED PECKING BEHAVIORQ3

DOPAMINEQ2

β-CARBOLINESQ3

HARMANEQ3

NORHARMANEQ2

HARMINEQ3

CHICKQ3

Abstract

Background and purpose: b-carboline alkaloids, also known as harmala's alkaloids have a wide spectrum of pharmacological actions including a stimulatory action on release of DOPAMINE and other catecholamines in several brain regions and an inhibitory action on monoamine oxidase (MAO). These findings suggest that b-carbolines should alleviate at least some of the DOPAMINErgic stereotyped behaviors. The purpose of present study is to determine the effects of b-carbolines HARMANE, NORHARMANE and HARMINE on apomorphine-induced pecking behavior in CHICK.Materials and methods: All experiments were carried out on male/female CHICKs (40-60 g). The modulatory effects of b-Carbolines on stereotyped behavior were assessed using the pecking behavior induced by apomorphine. Subcutaneous (s.c.) injection of apomorphaine (0.025 mg/kg, mixed agonist of DOPAMINE D1/D2 receptors) induced pecking. The pecking response was counted by direct observation and recorded for a 40-minute period.Results: S.C. injection of HARMANE (2.5-10 mg/kg) and HARMINE (1.25-5 mg/kg) significantly decreased the pecking behavior induced by apomorphine (0.25 mg/kg). The NORHARMANE (2.5-15 mg/kg, i.p.) response was biphasic. The inhibitory effects of HARMANE, NORHARMANE and HARMINE were blocked by flumazenil (5 mg/kg, i.e., 30 minutes before the test) or reserpine (5 mg/kg, i.e., 18 hours before the test).Conclusion: Results suggest that the modulatory effect of HARMANE, NORHARMANE and HARMINE on the pecking behavior may be mediated through an inverse agonistic/monoaminergic mechanism.

Cites

THE EFFECT OF SYNCHRONUS INTRAPERITONEAL INJECTION OF HARMALINE AND PTZ ON SEROTONERGIC AND GABAERGIC PATHWAYS AND SEIZURE THRESHOLD IN NMRI MALE MICE

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APA: Copy

FARZIN, D., & SALIMI, E.. (2009). EFFECTS OF HARMANE, NORHARMANE AND HARMINE ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN CHICK. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 19(70), 1-8. SID. https://sid.ir/paper/44942/en

Vancouver: Copy

FARZIN D., SALIMI E.. EFFECTS OF HARMANE, NORHARMANE AND HARMINE ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN CHICK. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;19(70):1-8. Available from: https://sid.ir/paper/44942/en

IEEE: Copy

D. FARZIN, and E. SALIMI, “EFFECTS OF HARMANE, NORHARMANE AND HARMINE ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN CHICK,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 70, pp. 1–8, 2009, [Online]. Available: https://sid.ir/paper/44942/en

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