EVALUATION OF ANTIDEPRESSANT ACTIVITIES OF HARMANE, NORHARMAN AND HARMINE IN MICE

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FARZIN D.; MANSOURI N.A.

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2005 | Volume:6 | Issue:14 Page(s): 1-9

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Title

EVALUATION OF ANTIDEPRESSANT ACTIVITIES OF HARMANE, NORHARMAN AND HARMINE IN MICE

Author(s)

FARZIN D. | MANSOURI N.A. | Issue Writer Certificate

Keywords

DEPRESSIONQ2

FORCED SWIM TESTQ1

Â-CARBOLINESQ3

HARMANEQ3

NORHARMANEQ2

HARMINEQ3

MICEQ2

Abstract

Background&Objective: It has been reported that, the â-carboline alkaloids of peganum harmala seeds have a stimulatory action on serotonin and catecholamines releases in different brain regions. In addition, one of the most important pharmacological effects demonstrated for â- carbolines is a revesible inhibitory action on MAO-A. These findings suggest that Â-CARBOLINES, should alleviate at least some of the signs of DEPRESSION. The purpose of present study is to determine the antidepressant activity of Â-CARBOLINES HARMANE, NORHARMANE and HARMINE. Materials&Methods: All experiments were carried out on male Swiss-Webster mice (25-30g). The antidepressant activities of the Â-CARBOLINES were assessed using the forced swim test. This test is the most widely used tool for antidepressant activity preclinically. In this test, MICE were placed into a cylinderical glass (25 cm height, 12 cm in diameter) containing a column of 15 cm of water at 25 ±1 °C. After 30 min of the Â-CARBOLINES injections, the mice were subjected to forced swimming test for 8 min and their immobility time was recorded. Results: Intrperitoneal (i.p.) injections of HARMANE (5-15 mg/kg), NORHARMANE (2.5-10 mg/kg) and HARMINE (5-15 mg/kg) significantly decreased the immobility time in the mouse forced swim test. The inhibitory effects of HARMANE, NORHARMANE and HARMINE were antagonized by flumazenil (5 mg/kg, i.p.) but not by reserpine (5 mg/kg, i.p., 18 h before test). Conclusion: The results suggest that the antidepressant activities of HARMANE, NORHARMANE and harmine may be mediated through an inverse agonistic mechanism.

Cites

THE EFFECT OF SYNCHRONUS INTRAPERITONEAL INJECTION OF HARMALINE AND PTZ ON SEROTONERGIC AND GABAERGIC PATHWAYS AND SEIZURE THRESHOLD IN NMRI MALE MICE

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APA: Copy

FARZIN, D., & MANSOURI, N.A.. (2005). EVALUATION OF ANTIDEPRESSANT ACTIVITIES OF HARMANE, NORHARMAN AND HARMINE IN MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 6(14), 1-9. SID. https://sid.ir/paper/79059/en

Vancouver: Copy

FARZIN D., MANSOURI N.A.. EVALUATION OF ANTIDEPRESSANT ACTIVITIES OF HARMANE, NORHARMAN AND HARMINE IN MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;6(14):1-9. Available from: https://sid.ir/paper/79059/en

IEEE: Copy

D. FARZIN, and N.A. MANSOURI, “EVALUATION OF ANTIDEPRESSANT ACTIVITIES OF HARMANE, NORHARMAN AND HARMINE IN MICE,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 6, no. 14, pp. 1–9, 2005, [Online]. Available: https://sid.ir/paper/79059/en

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