THE EFFECT OF GONADECTOMY AND SEX – RELATED DIFFERENCES IN RESPONSE TO MATRICARIA CHAMOMILLA EXTRACT ON LOCOMOTOR ACTIVITY BEHAVIOR IN MICE

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RAEI H.; KESMATI M.; ZADKARAMI M.R.

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2007 | Volume:17 | Issue:58 Page(s): 43-56

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Title

THE EFFECT OF GONADECTOMY AND SEX – RELATED DIFFERENCES IN RESPONSE TO MATRICARIA CHAMOMILLA EXTRACT ON LOCOMOTOR ACTIVITY BEHAVIOR IN MICE

Author(s)

RAEI H. | KESMATI M. | ZADKARAMI M.R. | Issue Writer Certificate

Keywords

MATRICARIA CHAMOMILLAQ3

OPEN FIELD TESTQ2

LOCOMOTOR ACTIVITYQ2

Abstract

Background and purpose: Former studies showed that the MATRICARIA CHAMOMILLA hedroalcholic extract affects pain and anxiety of male and female mice sex-dependently. In this research we examined the effect of MATRICARIA CHAMOMILLA (chamomile) hydroalcholic extract on LOCOMOTOR ACTIVITY behavior in presence and absence of sex glands in adult male and female NMRI mice. Materials and Methods: Animals were divided into groups of seven including intact, sham, gonadectomized and receiving hydroalcholic extract of chamomile (30 and 50 mg/kg i.p). Motor activity monitor system was used to evaluate LOCOMOTOR ACTIVITY parameters (number of line crossing movments, stereotype movments and number of rearing movments) in OPEN FIELD TEST on all groups. Results: 1) Hydroalcholic extract of chamomile (50 mg/kg dos) decreased motor activity parameters in presence and absence of sex glands in male mice. 2) Hydroalcholic extract of chamomile (50 mg/kg dose) increased motor activity parameters in presence and absence of sex glands in female mice.3) Gonadectomy did not have any effect on LOCOMOTOR ACTIVITY parameters on male mice.4) Gonadectomy decreased motor activity parameters on female mice.Conclusion: It seems that chamomile extract influences motor activity parameters via some sex related factors like neurochemical systems in male and female mice. This effect may in part depend on sex hormones receptors in female mice.

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APA: Copy

RAEI, H., KESMATI, M., & ZADKARAMI, M.R.. (2007). THE EFFECT OF GONADECTOMY AND SEX – RELATED DIFFERENCES IN RESPONSE TO MATRICARIA CHAMOMILLA EXTRACT ON LOCOMOTOR ACTIVITY BEHAVIOR IN MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 17(58), 43-56. SID. https://sid.ir/paper/45111/en

Vancouver: Copy

RAEI H., KESMATI M., ZADKARAMI M.R.. THE EFFECT OF GONADECTOMY AND SEX – RELATED DIFFERENCES IN RESPONSE TO MATRICARIA CHAMOMILLA EXTRACT ON LOCOMOTOR ACTIVITY BEHAVIOR IN MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;17(58):43-56. Available from: https://sid.ir/paper/45111/en

IEEE: Copy

H. RAEI, M. KESMATI, and M.R. ZADKARAMI, “THE EFFECT OF GONADECTOMY AND SEX – RELATED DIFFERENCES IN RESPONSE TO MATRICARIA CHAMOMILLA EXTRACT ON LOCOMOTOR ACTIVITY BEHAVIOR IN MICE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 58, pp. 43–56, 2007, [Online]. Available: https://sid.ir/paper/45111/en

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