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Information Journal Paper

Title

EFFECT OF CONTINUOUS AEROBIC EXERCISE ON BAX/ BCL-2 RATIO AND DOXORUBICIN-INDUCED LIVER TOXICITY IN AGING MODEL RATS

Pages

  36-46

Abstract

 Background and purpose: One of the main issues in cancer treatment is to reduce the sideeffects of drugs on healthy tissues. The aim of this study was to investigate the preventative effects ofcontinuous aerobic exercise on apoptosis ratio and liver fibrosis induced by DOXORUBICIN in AGING rats. Materials and methods: In this experimental research, 42 adult Wistar rats were randomlydivided into 6 groups (n= 7), including the Young, Aged, Aged+ Saline, Aged+ Dox, Aged+ Exercise+Saline, and Aged+ Exercise+ Dox. The training groups practiced on treadmill while considering theprinciple of overload (five sessions per week/ six weeks). On the last 15 days of exercise, DOXORUBICIN orsaline solution were injected (1 mg/kg/daily). Then, 48 hours after completing the trainings, liver tissuesampling was performed to evaluate the fibrosis and expression of Bax and Bcl-2 proteins. Data analysiswas done using One-way ANOVA at a significant level of P≤ 0. 05. Results: DOXORUBICIN caused a significant increase in liver fibrosis, expression of BAX PROTEINand Bax/Bcl-2 ratio, and a significant reduction in expression of Bcl-2 protein (p≤ 0. 05). On the otherhand, AEROBIC TRAINING significantly reduced the expression of BAX PROTEIN, Bax/Bcl-2 ratio and hepaticfibrosis, and significantly increased the expression of Bcl-2 protein (p≤ 0. 05). Conclusion: Continuous aerobic exercises, reduce the Bax/Bcl-2 ratio which is an indicator ofincrease in survival rate and also reduce liver fibrosis against DOXORUBICIN.

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    APA: Copy

    DADBAN SHAHAMAT, MINOO, DABIDI ROSHAN, VALIOLLAH, & FARAZMANDFAR, TOURAJ. (2018). EFFECT OF CONTINUOUS AEROBIC EXERCISE ON BAX/ BCL-2 RATIO AND DOXORUBICIN-INDUCED LIVER TOXICITY IN AGING MODEL RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(165 ), 36-46. SID. https://sid.ir/paper/45351/en

    Vancouver: Copy

    DADBAN SHAHAMAT MINOO, DABIDI ROSHAN VALIOLLAH, FARAZMANDFAR TOURAJ. EFFECT OF CONTINUOUS AEROBIC EXERCISE ON BAX/ BCL-2 RATIO AND DOXORUBICIN-INDUCED LIVER TOXICITY IN AGING MODEL RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(165 ):36-46. Available from: https://sid.ir/paper/45351/en

    IEEE: Copy

    MINOO DADBAN SHAHAMAT, VALIOLLAH DABIDI ROSHAN, and TOURAJ FARAZMANDFAR, “EFFECT OF CONTINUOUS AEROBIC EXERCISE ON BAX/ BCL-2 RATIO AND DOXORUBICIN-INDUCED LIVER TOXICITY IN AGING MODEL RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 165 , pp. 36–46, 2018, [Online]. Available: https://sid.ir/paper/45351/en

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