PROTECTIVE EFFECT OF CROCIN ON KIDNEY PERFORMANCE IN CHRONIC UNCONTROLLED HYPERGLYCEMIA-INDUCED NEPHROPATHY IN RAT

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YARIBEYGI H.; MOHAMMADI M.T.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2017 | Volume:25 | Issue:109 Page(s): 36-49

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Title

PROTECTIVE EFFECT OF CROCIN ON KIDNEY PERFORMANCE IN CHRONIC UNCONTROLLED HYPERGLYCEMIA-INDUCED NEPHROPATHY IN RAT

Author(s)

YARIBEYGI H. | MOHAMMADI M.T. | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

CROCINQ1

DIABETIC NEPHROPATHYQ2

OXIDATIVE STRESSQ2

HYPERGLYCEMIAQ1

Abstract

Background and Objective: Based on previous studies, inflammation and OXIDATIVE STRESS play a crucial role in the pathophysiology of DIABETIC NEPHROPATHY. Therefore, we aimed to examine the protective effects of CROCIN, as a potent anti-inflammatory and antioxidant, on kidney function and OXIDATIVE STRESS in an experimental model of DIABETIC NEPHROPATHY in male wistar rats.Materials and Methods: In this experimental study, male wistar rats (190-220 g) were randomly divided into four groups (each n=6); normal, normal treatment, diabetic, diabetic treatment. The rats were made diabetic by an intravenous injection of streptozotocin (40 mg/kg). Treated rats received CROCIN intraperitoneally with a dose of 40 mg/kg/day for eight weeks. Blood samples were collected for measurement of blood glucose and creatinine levels. The Malondialdehyde (MDA) and nitrate contents of kidney also were assessed.Results: Chronic HYPERGLYCEMIA (blood glucose>400 mg/dL) significantly increased the blood creatinine of the diabetic group (4.51±0.45 mg/dL) compared with normal rats (0.72±0.09 mg/dL, P<0.001). HYPERGLYCEMIA also decreased the nitrate content (37%) accompanied by an increase in the MDA content (13.00±0.19 µg/mg protein) compared with normal group (10.22±0.54 µg/mg protein). CROCIN significantly decreased the blood creatinine of diabetic rats (1.12±0.13 mg/dL, P<0.001), accompanied by a decrease in blood glucose (9%). Finally, the content of MDA significantly decreased by 29% in diabetic treated rats compare to diabetic untreated rats (P<0.001) Conclusion: Based on the findings of the present study, it is appeared that CROCIN has a role in the prevention of DIABETIC NEPHROPATHY through inhibition of OXIDATIVE STRESS and reducing lipid oxidation.

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APA: Copy

YARIBEYGI, H., & MOHAMMADI, M.T.. (2017). PROTECTIVE EFFECT OF CROCIN ON KIDNEY PERFORMANCE IN CHRONIC UNCONTROLLED HYPERGLYCEMIA-INDUCED NEPHROPATHY IN RAT. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 25(109), 36-49. SID. https://sid.ir/paper/61069/en

Vancouver: Copy

YARIBEYGI H., MOHAMMADI M.T.. PROTECTIVE EFFECT OF CROCIN ON KIDNEY PERFORMANCE IN CHRONIC UNCONTROLLED HYPERGLYCEMIA-INDUCED NEPHROPATHY IN RAT. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2017;25(109):36-49. Available from: https://sid.ir/paper/61069/en

IEEE: Copy

H. YARIBEYGI, and M.T. MOHAMMADI, “PROTECTIVE EFFECT OF CROCIN ON KIDNEY PERFORMANCE IN CHRONIC UNCONTROLLED HYPERGLYCEMIA-INDUCED NEPHROPATHY IN RAT,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 25, no. 109, pp. 36–49, 2017, [Online]. Available: https://sid.ir/paper/61069/en

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