ASSESSMENT OF CD93 STEM CELL GROWTH AND SURVIVAL ON THREE- DIMENSIONAL BIODEGRADABLE PCL-GELATIN SCAFFOLD

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ZAFARI FARIBA; SADEGHI MORTEZA; MOGHANLOO EHSAN; BAKHTIYARI MEHRDAD

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Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:26 | Issue:144 Page(s): 211-218

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Title

ASSESSMENT OF CD93 STEM CELL GROWTH AND SURVIVAL ON THREE- DIMENSIONAL BIODEGRADABLE PCL-GELATIN SCAFFOLD

Author(s)

ZAFARI FARIBA | SADEGHI MORTEZA | MOGHANLOO EHSAN | BAKHTIYARI MEHRDAD | Issue Writer Certificate

Keywords

NANO-FIBER SCAFFOLDQ1

POLYCAPROLACTONEQ1

CD93 STEM CELLSQ1

GROWTHQ1

REPRODUCTIONQ1

Abstract

Background and purpose: Application of three-dimensional scaffolds with the ability to simulate a three-dimensional in vivo environment has opened new perspective on targeted differentiation and therapeutic use of stem cells. In this study we examined the compatibility of CD93 STEM CELLS with biodegradable pcl- gelatin scaffold.Materials and methods: In this experimental study, three-dimensional scaffolds made of PCL - gelatin using electrospining synthesis and its molecular structure was tested by SEM electron microscopy. The scaffold surface was disinfected by UV ray. The hematopoietic CD93stem cells of those isolated previously were divided into two groups including normal cultured (plate) and culture on scaffolds (scaffold+cell). The survival and GROWTH of the cells were measured through MTT assay and electron microscopy at 7, 14, and 28 days after culturing.Results: Electron microscopic analysis on the seventh day showed appropriate adhesion of CD93 cells on scaffold fibers and secretion of extracellular matrix. Survival rate of the cells at 7, 14, and 28 days after culturing were not significantly different between the two groups. But at the same days significant differences were observed in the Scaffold+Cell group (P<0.05).Conclusion: This study suggests that PCL nanofiber scaffolds has high compatibility with CD93 STEM CELLS and proximity to this scaffold lead to increased survival and GROWTH of the cells. Further studies on the treatment of tissue damage and scarring by CD93 STEM CELLS using this scaffold can be effective in increasing treatment efficiency.

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APA: Copy

ZAFARI, FARIBA, SADEGHI, MORTEZA, MOGHANLOO, EHSAN, & BAKHTIYARI, MEHRDAD. (2017). ASSESSMENT OF CD93 STEM CELL GROWTH AND SURVIVAL ON THREE- DIMENSIONAL BIODEGRADABLE PCL-GELATIN SCAFFOLD. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(144), 211-218. SID. https://sid.ir/paper/45405/en

Vancouver: Copy

ZAFARI FARIBA, SADEGHI MORTEZA, MOGHANLOO EHSAN, BAKHTIYARI MEHRDAD. ASSESSMENT OF CD93 STEM CELL GROWTH AND SURVIVAL ON THREE- DIMENSIONAL BIODEGRADABLE PCL-GELATIN SCAFFOLD. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;26(144):211-218. Available from: https://sid.ir/paper/45405/en

IEEE: Copy

FARIBA ZAFARI, MORTEZA SADEGHI, EHSAN MOGHANLOO, and MEHRDAD BAKHTIYARI, “ASSESSMENT OF CD93 STEM CELL GROWTH AND SURVIVAL ON THREE- DIMENSIONAL BIODEGRADABLE PCL-GELATIN SCAFFOLD,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 144, pp. 211–218, 2017, [Online]. Available: https://sid.ir/paper/45405/en

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