ASSOCIATION BETWEEN FCY RIIA POLYMORPHISM AND BRUCELLOSIS

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RAFIEI B.; HOSSEINIKHAH Z.; AAJAMI A.; GHASEMIAN R.; MIRABI A.M.; HASANJANI ROSHAN M.R.; SOLTANINEZHAD H.A.; ASMAR M.

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Title

ASSOCIATION BETWEEN FCY RIIA POLYMORPHISM AND BRUCELLOSIS

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Keywords

BRUCELLOSISQ2

FC RIIAQ3

POLYMORPHISMQ3

Abstract

Background and purpose: BRUCELLOSIS is a major bacterial zoonosis of global importance.Effective host defence against brucella depends on immunoglobulin G-mediated phagocytosis of the bacteria and it has been shown that the FC RIIA POLYMORPHISM (FCg RIIA-R131 vs FCg RIIA -H13I) determines the capacity of immunoglobulin G-mediated phagocytosis via this receptor. The aim of this study was to evaluate the FCg RIIA POLYMORPHISM in patients with BRUCELLOSIS and to reveal any relation between this POLYMORPHISM and disease progression.Materials and Methods: In this study we evaluated FCg RIIA POLYMORPHISMs (R/R13I, R/H13I, H/H13I) in 67 patients with serologically proven BRUCELLOSIS and 67 healthy volunteers matched for age, sex and geographical area. FCg RIIA POLYMORPHISM was determined using a polymerase chain reaction method (SSCP-PCR).Results: The frequency of FCg RIIA-R/R131 genotype was higher in patients with BRUCELLOSIS compared with controls (47.8% vs 28.4%). This genotype has a (OR=2.1, 95%CI=1.3-4.2, P=0.039) significant correlation with BRUCELLOSIS. However, no significant difference was found between patients with BRUCELLOSIS and controls (P=0.2)Although the frequency of FCg RIIA-R/R131 was higher in patients with BRUCELLOSIS compared with controls, we did not find any statistically significant differences (53.8% vs46.3%, P=0.2). As a result, there was no significant association between FCgRIIA genotype and severity of BRUCELLOSIS. Conclusion: Based on the results, the dominance of homozygous genotype of FCg RIIA-R/R13 I III patients with bracellosis emphasize the importance of this predisposing genetic risk factor in contracting the disease.

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APA: Copy

RAFIEI, B., HOSSEINIKHAH, Z., AAJAMI, A., GHASEMIAN, R., MIRABI, A.M., HASANJANI ROSHAN, M.R., SOLTANINEZHAD, H.A., & ASMAR, M.. (2007). ASSOCIATION BETWEEN FCY RIIA POLYMORPHISM AND BRUCELLOSIS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 16(56), 21-28. SID. https://sid.ir/paper/45627/en

Vancouver: Copy

RAFIEI B., HOSSEINIKHAH Z., AAJAMI A., GHASEMIAN R., MIRABI A.M., HASANJANI ROSHAN M.R., SOLTANINEZHAD H.A., ASMAR M.. ASSOCIATION BETWEEN FCY RIIA POLYMORPHISM AND BRUCELLOSIS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;16(56):21-28. Available from: https://sid.ir/paper/45627/en

IEEE: Copy

B. RAFIEI, Z. HOSSEINIKHAH, A. AAJAMI, R. GHASEMIAN, A.M. MIRABI, M.R. HASANJANI ROSHAN, H.A. SOLTANINEZHAD, and M. ASMAR, “ASSOCIATION BETWEEN FCY RIIA POLYMORPHISM AND BRUCELLOSIS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 56, pp. 21–28, 2007, [Online]. Available: https://sid.ir/paper/45627/en

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