LOVASTATIN ENHANCES PARAOXONASE ENZYME ACTIVITY AND QUELLS LOW-DENSITY LIPOPROTEIN SUSCEPTIBILITY TO OXIDATION IN TYPE 2 DIABETIC NEPHROPATHY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAGHAVI BEHZAD MOHAMMAD; NEZAMI NARIMAN; PIRI REZA; SAFA JAVID; SALARI BEHZAD; RASHTCHI ZADEH NADEREH; GHORBANIHAGHJO AMIR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2013 | Volume:35 | Issue:2 Page(s): 90-97

Download Full-Text

Persian Verion

View:

759

Download:

Cites:

Information Journal Paper

Title

LOVASTATIN ENHANCES PARAOXONASE ENZYME ACTIVITY AND QUELLS LOW-DENSITY LIPOPROTEIN SUSCEPTIBILITY TO OXIDATION IN TYPE 2 DIABETIC NEPHROPATHY

Author(s)

Keywords

DIABETESQ2

NEPHROPATHYQ2

LIPID PEROXIDATIONQ2

ARYLESTERASEQ2

LOVASTATINQ2

Abstract

Background & Objectives: This study was done to investigate the effect of LOVASTATIN therapy on paraoxonase 1 (PON1) and ARYLESTERASE (ARE) activities, and low-density lipoprotein cholesterol (LDL-C) susceptibility to oxidation in people with type 2 diabetic NEPHROPATHY (T2DN).& Methods: LOVASTATIN (20 mg/day) was administered to 30 people with T2DN for 90 days and then withdrawn for 30 days. PON1 and ARE activities were measured by the spectrophotometric method. Susceptibility of LDL-C to oxidation was determined as the production of conjugated dienes.Results: After 90 days of LOVASTATIN intervention, PON1 and ARE activities and LDL-C lag phase were significantly increased (p=0.004, 0.002, and b0.001). After 30 days of LOVASTATIN withdrawal, PON1 and ARE activities and LDL-C lag phase had not changed significantly.Conclusion: LOVASTATIN therapy improves PON1 and ARE activities, and LDL-C susceptibility to oxidation. Despite withdrawal of LOVASTATIN, PON1 and ARE activities, and LDL-C susceptibility to oxidation remain unchanged for a long period of time in people with T2DN.

Cites

No record.

References

No record.

Cite

APA: Copy

NAGHAVI BEHZAD, MOHAMMAD, NEZAMI, NARIMAN, PIRI, REZA, SAFA, JAVID, SALARI, BEHZAD, RASHTCHI ZADEH, NADEREH, & GHORBANIHAGHJO, AMIR. (2013). LOVASTATIN ENHANCES PARAOXONASE ENZYME ACTIVITY AND QUELLS LOW-DENSITY LIPOPROTEIN SUSCEPTIBILITY TO OXIDATION IN TYPE 2 DIABETIC NEPHROPATHY. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 35(2), 90-97. SID. https://sid.ir/paper/47396/en

Vancouver: Copy

NAGHAVI BEHZAD MOHAMMAD, NEZAMI NARIMAN, PIRI REZA, SAFA JAVID, SALARI BEHZAD, RASHTCHI ZADEH NADEREH, GHORBANIHAGHJO AMIR. LOVASTATIN ENHANCES PARAOXONASE ENZYME ACTIVITY AND QUELLS LOW-DENSITY LIPOPROTEIN SUSCEPTIBILITY TO OXIDATION IN TYPE 2 DIABETIC NEPHROPATHY. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;35(2):90-97. Available from: https://sid.ir/paper/47396/en

IEEE: Copy

MOHAMMAD NAGHAVI BEHZAD, NARIMAN NEZAMI, REZA PIRI, JAVID SAFA, BEHZAD SALARI, NADEREH RASHTCHI ZADEH, and AMIR GHORBANIHAGHJO, “LOVASTATIN ENHANCES PARAOXONASE ENZYME ACTIVITY AND QUELLS LOW-DENSITY LIPOPROTEIN SUSCEPTIBILITY TO OXIDATION IN TYPE 2 DIABETIC NEPHROPATHY,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 35, no. 2, pp. 90–97, 2013, [Online]. Available: https://sid.ir/paper/47396/en

Related Journal Papers