SERUM COPPER STATUS IN WOMEN USERS OF LOW-DOSE ORAL CONTRACEPTIVES AND IN POSTMENOPAUSAL WOMEN TAKING HORMONE REPLACEMENT THERAPY

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RAFRAF M.; MAHDAVI R.; RASHIDI M.R.; HASANZADEH D.

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Journal: PHARMACEUTICAL SCIENCES Year:2003 | Volume:- | Issue:1 Page(s): 73-82

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Title

SERUM COPPER STATUS IN WOMEN USERS OF LOW-DOSE ORAL CONTRACEPTIVES AND IN POSTMENOPAUSAL WOMEN TAKING HORMONE REPLACEMENT THERAPY

Author(s)

RAFRAF M. | MAHDAVI R. | RASHIDI M.R. | HASANZADEH D. | Issue Writer Certificate

Keywords

COPPERQ2

ORAL CONTRACEPTIVESQ3

HORMONE REPLACEMENT THERAPYQ3

Abstract

The objective of this study was to investigate the serum COPPER status in women who use low-dose ORAL CONTRACEPTIVES (OCPs) containing 0.15 mg levonorgestrol and 0.03 mg ethinyl estradiol and also in postmenopausal women who take HORMONE REPLACEMENT THERAPY (HRT). In these two case-control studies, one hundred-thrity five healthy nonpregnant-nonlactating women, with a mean age of 32 years (70 were OCPs users and 65 were non-OCP susers) and fifty-nine healthy postmenopausal women, with a mean age of 51 years (29 were under HRT and 30 were untreated) were studied using biochemical procedurs, anthropometric measurments and interview with the subjects. No significant difference was found between either OCPs and non-OCPs users or HRT and non-HRT groups in terms of mean BMI, number of pregnancies and COPPER intake. Mean serum COPPER concentration in OCPs users was significantly (P<0.0001) higher than that of non-OCPs users (162.3±36.5 µg/dl vs 112.3±29.6 µg/dl). Mean serum COPPER concentration in HRT group was also significantly (P<0.002) higher than that of non- HRT group (144.2±25.5 µg/dl vs 122.5±24.9 µg/dl). There was a significant (P<0.0001) relationship between serum COPPER status and use of OCPs analyzed using X2 test .This test did not show significant relationship in postmenopausal women. No significant correlation was found between serum COPPER concentration and age, BMI, number of pregnancies and COPPER intake in all groups. As a conclusion, the serum COPPER concentration increases in oral contraceptive users and the further evidence was provided by this study indicative of an increase in serum COPPER concentration of postmenopausal women who take, hormonal replacement therapy.

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APA: Copy

RAFRAF, M., MAHDAVI, R., RASHIDI, M.R., & HASANZADEH, D.. (2003). SERUM COPPER STATUS IN WOMEN USERS OF LOW-DOSE ORAL CONTRACEPTIVES AND IN POSTMENOPAUSAL WOMEN TAKING HORMONE REPLACEMENT THERAPY. PHARMACEUTICAL SCIENCES, -(1), 73-82. SID. https://sid.ir/paper/48707/en

Vancouver: Copy

RAFRAF M., MAHDAVI R., RASHIDI M.R., HASANZADEH D.. SERUM COPPER STATUS IN WOMEN USERS OF LOW-DOSE ORAL CONTRACEPTIVES AND IN POSTMENOPAUSAL WOMEN TAKING HORMONE REPLACEMENT THERAPY. PHARMACEUTICAL SCIENCES[Internet]. 2003;-(1):73-82. Available from: https://sid.ir/paper/48707/en

IEEE: Copy

M. RAFRAF, R. MAHDAVI, M.R. RASHIDI, and D. HASANZADEH, “SERUM COPPER STATUS IN WOMEN USERS OF LOW-DOSE ORAL CONTRACEPTIVES AND IN POSTMENOPAUSAL WOMEN TAKING HORMONE REPLACEMENT THERAPY,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 73–82, 2003, [Online]. Available: https://sid.ir/paper/48707/en

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