EFFECT OF THERMAL-TREATING ON THE RELEASE OF THEOPHYLLINE HCI FROM THE GRANULES PREPARED USING ACRYLIC POLYMERS

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AZARMI SH.; HATAMKHANI SH.; MONAJEMZADEH F.; MOHAMMADI GH.

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Journal: PHARMACEUTICAL SCIENCES Year:2006 | Volume:- | Issue:4 Page(s): 17-26

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Title

EFFECT OF THERMAL-TREATING ON THE RELEASE OF THEOPHYLLINE HCI FROM THE GRANULES PREPARED USING ACRYLIC POLYMERS

Author(s)

AZARMI SH. | HATAMKHANI SH. | MONAJEMZADEH F. | MOHAMMADI GH. | Issue Writer Certificate

Keywords

THERMAL- TREATINGQ2

THEOPHYLLINEQ2

EUDRAGITQ2

DISSOLUTIONQ2

Abstract

Objectives: The purpose of this study was to investigate the effect of thermal-treating on the release of THEOPHYLLINE HCl from the granules which have been prepared using aqueous dispersions of EUDRAGIT. Methods: To accomplish this goal, different granules were prepared using wet granulation method containing three different types of EUDRAGIT aqueous dispersions, NE40D, RS30D, RL30D and dicalcium phosphate. The drug release studies were conducted using USP DISSOLUTION apparatus. The concentration of released drug was analyzed using DV spectrophotometer at 271.4 nm. Since the drug release from granules was nearly completed at the first hour, for thermal-treating studies, tablets were prepared using direct compression method. The prepared tablets were thermally treated at 50 and 70°C for 24 hours. Release of drug was assessed before and after thermal-treating. Results: The results of release study showed that, thermally-treating the tablets at the temperatures higher than Tg of the polymer can decrease the drug release from matrices. For mechanistic evaluation of the effect of thermal-treating, XRD, SEM, DSC and FT-IR have been employed. SEM micrographs showed that the tablets have smoother surface with less porosity after thermal-treating. XRD difractograms showed that during granulation, monohydrate THEOPHYLLINE has been formed but there was no obvious crystal change between control and thermal-treated tablets. FT-IR spectra showed a hydrogen bonding between EUDRAGIT and drug but there was no change in the spectrum of thermally-treated tablet compared to control. In DSC thermograrns, endothermic peak of the melting point of THEOPHYLLINE has been disappeared which it can be likely due to the solvation of the drug in polymer during the recording of DSC spectrum. Conclusion: Heat treating of Eudrag it over the Tg can rotard the drug release from its matrices.

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APA: Copy

AZARMI, SH., HATAMKHANI, SH., MONAJEMZADEH, F., & MOHAMMADI, GH.. (2006). EFFECT OF THERMAL-TREATING ON THE RELEASE OF THEOPHYLLINE HCI FROM THE GRANULES PREPARED USING ACRYLIC POLYMERS. PHARMACEUTICAL SCIENCES, -(4), 17-26. SID. https://sid.ir/paper/48739/en

Vancouver: Copy

AZARMI SH., HATAMKHANI SH., MONAJEMZADEH F., MOHAMMADI GH.. EFFECT OF THERMAL-TREATING ON THE RELEASE OF THEOPHYLLINE HCI FROM THE GRANULES PREPARED USING ACRYLIC POLYMERS. PHARMACEUTICAL SCIENCES[Internet]. 2006;-(4):17-26. Available from: https://sid.ir/paper/48739/en

IEEE: Copy

SH. AZARMI, SH. HATAMKHANI, F. MONAJEMZADEH, and GH. MOHAMMADI, “EFFECT OF THERMAL-TREATING ON THE RELEASE OF THEOPHYLLINE HCI FROM THE GRANULES PREPARED USING ACRYLIC POLYMERS,” PHARMACEUTICAL SCIENCES, vol. -, no. 4, pp. 17–26, 2006, [Online]. Available: https://sid.ir/paper/48739/en

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