COMPARATIVE EXPRESSION OF BREAST CANCER 1 TUMOR SUPPRESSOR PROTEIN IN CANCEROUS AND HEALTHY COLORECTAL SPECIMENS

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NIKBAKHT DASTJERDI MEHDI; KASHANIAN VAHID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Isfahan Medical School Year:2016 | Volume:33 | Issue:368 Page(s): 2455-2460

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Title

COMPARATIVE EXPRESSION OF BREAST CANCER 1 TUMOR SUPPRESSOR PROTEIN IN CANCEROUS AND HEALTHY COLORECTAL SPECIMENS

Author(s)

NIKBAKHT DASTJERDI MEHDI | KASHANIAN VAHID | Issue Writer Certificate

Keywords

COLORECTAL CANCERQ2

IMMUNOHISTOCHEMISTRYQ2

BREAST CANCER 1 (BRCA1)Q2

TUMOR INHIBITOR GENEQ2

Abstract

Background: Various tumor suppressor genes play a role in COLORECTAL CANCER; the role of breast cancer 1 (BRCA1) tumor suppressor gene is of the most importance among them. The biological performance of breast cancer 1 (BRCA1) in cancer has been recognized and its prognostic significance has been verified in COLORECTAL CANCER; decrease in the expression of this protein in cancer indicates a poor prognosis for patients. The aim of the current study was to evaluate BRCA1 protein expression in cancerous colorectal specimens compared to healthy tissue surrounding the tumor using IMMUNOHISTOCHEMISTRY method.Methods: A total of 50 cancerous colorectal and 50 healthy specimens were collected. The expression of BRCA1 protein was evaluated upon paraffin sections through IMMUNOHISTOCHEMISTRY method.Findings: The findings of the current study showed that the level of BRCA1 protein expression significantly decreased in cancerous specimens compared to healthy tissue surrounding the tumor (P=0.026).Conclusion: The expression of BRCA1 could be used as an appropriate biological marker in the diagnosis and prognosis of COLORECTAL CANCER.

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APA: Copy

NIKBAKHT DASTJERDI, MEHDI, & KASHANIAN, VAHID. (2016). COMPARATIVE EXPRESSION OF BREAST CANCER 1 TUMOR SUPPRESSOR PROTEIN IN CANCEROUS AND HEALTHY COLORECTAL SPECIMENS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 33(368), 2455-2460. SID. https://sid.ir/paper/50204/en

Vancouver: Copy

NIKBAKHT DASTJERDI MEHDI, KASHANIAN VAHID. COMPARATIVE EXPRESSION OF BREAST CANCER 1 TUMOR SUPPRESSOR PROTEIN IN CANCEROUS AND HEALTHY COLORECTAL SPECIMENS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;33(368):2455-2460. Available from: https://sid.ir/paper/50204/en

IEEE: Copy

MEHDI NIKBAKHT DASTJERDI, and VAHID KASHANIAN, “COMPARATIVE EXPRESSION OF BREAST CANCER 1 TUMOR SUPPRESSOR PROTEIN IN CANCEROUS AND HEALTHY COLORECTAL SPECIMENS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 33, no. 368, pp. 2455–2460, 2016, [Online]. Available: https://sid.ir/paper/50204/en

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