EFFECT OF N-3 FATTY ACIDS SUPPLEMENTATION ON PRODUCTION OF INFLAMMATORY CYTOKINES BY PERIPHERAL MONONUCLEAR CELLS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAABANI Y.; RASTMANESH S.R.; KAVIANI SAEID; JAMSHIDI A.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2009 | Volume:27 | Issue:97 Page(s): 353-365

Download Full-Text

Persian Verion

View:

1,415

Download:

Cites:

Information Journal Paper

Title

EFFECT OF N-3 FATTY ACIDS SUPPLEMENTATION ON PRODUCTION OF INFLAMMATORY CYTOKINES BY PERIPHERAL MONONUCLEAR CELLS

Author(s)

SHAABANI Y. | RASTMANESH S.R. | KAVIANI SAEID | JAMSHIDI A.R. | Issue Writer Certificate

Keywords

RHEUMATOID ARTHRITISQ3

PBMCQ3

N-3 FATTY ACIDSQ3

VITAMIN EQ2

Abstract

Background: Increased dietary consumption of the n-3 polyunsaturated fatty acids (PUFA) eicosapetaenoic acid (20: 5n-3; EPA) and docosahexaenoic acid (22: 6n-6; DHA) is associated with their incorporation into circulating phospholipid and increased production of lipid peroxide metabolites. The relationship between peripheral blood mononuclear cell (PBMC) function, n-3 PUFA intake and antioxidant cosupplementation is poorly defined in RHEUMATOID ARTHRITIS (RA) patients. This study was designed to evaluate tumor necrosis factor-a (TNF-a) and interleukin (IL) 6 production by PBMC in RA. Methods: Fifty-five patients (50 female, 5 male; mean age = 47 ± 11 years) were investigated in three groups in a randomized double-blind clinical trial. Patients were randomly assigned to one of these three groups: group 1 (G1) was received placebo (MCT oil, 2 g/d plus VITAMIN E placebo), the second group (G2) was received N-3 FATTY ACIDS (1.2 g/d; EPA/DHA plus VITAMIN E placebo), and the third group (G3) was received N-3 FATTY ACIDS (1.2 g/d; EPA/DHA) plus 100 IU/d VITAMIN E. Medication dose was intact during the study. Data were compared between groups using analysis of variance (ANOVA).Findings: Fish oil N-3 FATTY ACIDS supplementation of diet decreased production of TNF-a (P = 0.007) by stimulated PBMC in G2 and G3 in relation to G1. Also G3 in relation to G2 and G1 showed significant decrease with respect to malonaldehyde (MDA) (P = 0.005).Conclusion: Consumption of omega-3 fatty acids with VITAMIN E not only decreased production of inflammatory parameters but also decreased lipid per-oxidation in RA patients.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAABANI, Y., RASTMANESH, S.R., KAVIANI, SAEID, & JAMSHIDI, A.R.. (2009). EFFECT OF N-3 FATTY ACIDS SUPPLEMENTATION ON PRODUCTION OF INFLAMMATORY CYTOKINES BY PERIPHERAL MONONUCLEAR CELLS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 27(97), 353-365. SID. https://sid.ir/paper/50561/en

Vancouver: Copy

SHAABANI Y., RASTMANESH S.R., KAVIANI SAEID, JAMSHIDI A.R.. EFFECT OF N-3 FATTY ACIDS SUPPLEMENTATION ON PRODUCTION OF INFLAMMATORY CYTOKINES BY PERIPHERAL MONONUCLEAR CELLS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2009;27(97):353-365. Available from: https://sid.ir/paper/50561/en

IEEE: Copy

Y. SHAABANI, S.R. RASTMANESH, SAEID KAVIANI, and A.R. JAMSHIDI, “EFFECT OF N-3 FATTY ACIDS SUPPLEMENTATION ON PRODUCTION OF INFLAMMATORY CYTOKINES BY PERIPHERAL MONONUCLEAR CELLS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 27, no. 97, pp. 353–365, 2009, [Online]. Available: https://sid.ir/paper/50561/en

Related Journal Papers