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Information Journal Paper

Title

PRIMARY GASREOINTESTINAL LYMPHOMAS A PATHOLOGIC STUDY WITH CELL TYPING

Pages

  11-18

Abstract

 Introduction: Billroth first described Non-Hodgkins LYMPHOMA (NHL) with primary gastrointestinal localization (GI-NHL) in 1871. GI-NHL represents only 1-4% of the malignant tumours in the GASTROINTESTINAL TRACT, however, the GASTROINTESTINAL TRACT is the most common extranodal site of NHL. The disease predominantly affects the elderly with a median age of 60-70 years and a male: female ratio of about 2: 1. This study was undertaken to evaluate the epidemiology and histoligical features of GI-NHL specially using the recently introduced Revised European-American LYMPHOMA (REAL) classification, and Immunohistochemical staining with LCA, CD3 and CD20 for differentiation of T and B cell LYMPHOMAs.Material and Methods: From the 103573 Tissue Specimens during a 22 years Period (1981- 2003) in pathology archive of Emam Reza hospital of MashhAd, all with definite, differential or probable diagnosis of GI LYMPHOMA were specified and reevaluated applying routine H/E, histochemical and new immunohistochemical staining. 65 were diagnosed as definite GI LYMPHOMA, which were further stained for CD20and CD3 markers to determine their cell type.Finally they were reclassified according to REAL classification and their epidemiologic and pathologic features were specified.Results: Male: female distribution was 1.5:1. A peak incidence in the GI-NHL during the second to the third decade of life is observed. Eight patients (12.3%) had primary LYMPHOMA in the stomach, 52(80%) in the small intestine, 2 (3%) in the large intestine and three (4.7 %) patients had ileocecal involvement. According to the Revised European-American LYMPHOMA (REAL) classification, IPSID LYMPHOMA was the most frequent histologic subtype comprising 40% of the cases. Sixty-four cases were classified as B-cell LYMPHOMAs, and only one as T-cell type.  

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  • Cite

    APA: Copy

    KHOUEI, A.R., MAHMOUDI, M., & FARZADNIA, M.. (2004). PRIMARY GASREOINTESTINAL LYMPHOMAS A PATHOLOGIC STUDY WITH CELL TYPING. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 47(83), 11-18. SID. https://sid.ir/paper/51306/en

    Vancouver: Copy

    KHOUEI A.R., MAHMOUDI M., FARZADNIA M.. PRIMARY GASREOINTESTINAL LYMPHOMAS A PATHOLOGIC STUDY WITH CELL TYPING. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2004;47(83):11-18. Available from: https://sid.ir/paper/51306/en

    IEEE: Copy

    A.R. KHOUEI, M. MAHMOUDI, and M. FARZADNIA, “PRIMARY GASREOINTESTINAL LYMPHOMAS A PATHOLOGIC STUDY WITH CELL TYPING,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 47, no. 83, pp. 11–18, 2004, [Online]. Available: https://sid.ir/paper/51306/en

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