THE EFFECT OF A HERBAL PREPARATION, ACA1 ON ACTIVATION AND NITRIC OXIDE PRODUCTION OF BALB/C MICE PRETONEAL MACROPHAGES

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GHAZANFARI T.; YARAEE ROYA; NASERI M.; SANAYEI A.; EBRAHIMI R.

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Journal: Iranian Journal of Basic Medical Sciences Year:2007 | Volume:10 | Issue:1 (33) Page(s): 8-14

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Title

THE EFFECT OF A HERBAL PREPARATION, ACA1 ON ACTIVATION AND NITRIC OXIDE PRODUCTION OF BALB/C MICE PRETONEAL MACROPHAGES

Author(s)

Keywords

IMMUNOMODULATIONQ3

PERITONEAL MACROPHAGEQ3

NOQ2

ACA1Q2

HERBAL MEDICINEQ2

Abstract

ACA1 is a preparation of an Iranian medicinal herb which would be used in Iranian Traditional Medicine (ITM). Our previous studies have been shown that ACA1 causes a cytotoxic effect on AGS and SK-MEL3 in vitro. The purpose of this study is the evaluation of immunomodulatory effect of ACA1 on macrophage response.Materials and MethodsIntraperitoneal macrophage activation and proliferation was evaluated after 5 day I.P. injection of ACA1 by the use of MTT assay. Nitric oxide (NO) production was determined by Grees method.Results Our data showed that MTT reduction significantly increased by intraperitoneal macrophages from 20 mg/kg ACA1 treated mice in the presence of PMA (p < 0.001). NO production significantly increased in all test groups in comparison with control group (p< 0.01).ConclusionThe results of this study demonstrated that ACA1 induces the activation and NO production of intraperitoneal macrophage.

Cites

THE EFFECT OF WATER SOLUBLE CAROTENOIDS OF SAFFRON ON CELL-MEDIATED IMMUNITY IN BALB/C MICE

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APA: Copy

GHAZANFARI, T., YARAEE, ROYA, NASERI, M., SANAYEI, A., & EBRAHIMI, R.. (2007). THE EFFECT OF A HERBAL PREPARATION, ACA1 ON ACTIVATION AND NITRIC OXIDE PRODUCTION OF BALB/C MICE PRETONEAL MACROPHAGES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 10(1 (33)), 8-14. SID. https://sid.ir/paper/52429/en

Vancouver: Copy

GHAZANFARI T., YARAEE ROYA, NASERI M., SANAYEI A., EBRAHIMI R.. THE EFFECT OF A HERBAL PREPARATION, ACA1 ON ACTIVATION AND NITRIC OXIDE PRODUCTION OF BALB/C MICE PRETONEAL MACROPHAGES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2007;10(1 (33)):8-14. Available from: https://sid.ir/paper/52429/en

IEEE: Copy

T. GHAZANFARI, ROYA YARAEE, M. NASERI, A. SANAYEI, and R. EBRAHIMI, “THE EFFECT OF A HERBAL PREPARATION, ACA1 ON ACTIVATION AND NITRIC OXIDE PRODUCTION OF BALB/C MICE PRETONEAL MACROPHAGES,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 10, no. 1 (33), pp. 8–14, 2007, [Online]. Available: https://sid.ir/paper/52429/en

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