HISTOLOGICAL EVALUATION OF THE ANTI-INFLAMMATORY EFFECTS OF ALKANNA TINCTORIA ON THE CUTANEOUS WOUNDS HEALING IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SEDAGHAT REZA; GHOSIAN MOGHADAM M.H.; NASERI MOHSEN; DAVATI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Hormozgan Medical Journal Year:2011 | Volume:14 | Issue:4 Page(s): 281-289

Download Full-Text

Persian Verion

View:

1,267

Download:

Cites:

Information Journal Paper

Title

HISTOLOGICAL EVALUATION OF THE ANTI-INFLAMMATORY EFFECTS OF ALKANNA TINCTORIA ON THE CUTANEOUS WOUNDS HEALING IN RAT

Author(s)

SEDAGHAT REZA | GHOSIAN MOGHADAM M.H. | NASERI MOHSEN | DAVATI A. | Issue Writer Certificate

Keywords

ANTI INFLAMMATORY AGENTQ3

WOUND HEALINGQ2

RATQ2

Abstract

Introduction: Searching the methods improving WOUND HEALING is always one of the major subjects of interest. Alkanna tinctoria is applied as a wound dressing since ancient times in traditional medicine; however its healing effects was not evaluated histologically. Methods: 96 male Sprague – Dawley RATs were randomly divided into three (experimental, placebo, and control) groups. On the basis of defined periods, each group was subdivided into four subgroups with eight RATs in each subgroup. Animals were anesthetized with intraperitoneal injection of Ketamine hydrochloride and Xylazine, and a full-thickness incision was made on the skin of each RAT at the side of back region. Experimental and placebo groups received treatment with Alkanna tinctoria root ointment and Vaseline, respectively. Treatment was continued twice a day till euthanasia on defined periods. Control group received no treatment. Animals were euthanized with intracardiac injection of Ketamine hydrochloride in defined periods. A specimen were taken from the injured area and was placed in 10% formalin solution. The specimens were processed and sectioned in 5 micrometers. Sections were stained with Hematoxylin and Eosin and studied microscopically. Finally, the data were analyzed statistically using Kruskal-Wallis test. Differences were considered significant at P<0.05. Results: Data showed significant (P<0.05) difference in extent of inflammation (day 7), intensity of inflammation (days 5 and 7) among experimental, placebo, and control groups. Conclusion: The findings demonstrated that Alkanna tinctoria cxhibit anti-inflammatory effect(s) and could improve WOUND HEALING through reducing extent and intensity of inflammation.

Cites