INVOLVEMENT OF α-1-ADRENERGIC RECEPTORS IN CENTRAL REGION OF AMYGDALA AND THE EFFECTS OF CANNABINOID AGONIST ON INHIBITORY AVOIDANCE MEMORY IN MALE RATS

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MOSHFEGH A.; YARABI A.R.; TEHRANIFARD A.; DASTAN K.

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Journal: Hormozgan Medical Journal Year:2015 | Volume:18 | Issue:5 Page(s): 397-409

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Title

INVOLVEMENT OF α-1-ADRENERGIC RECEPTORS IN CENTRAL REGION OF AMYGDALA AND THE EFFECTS OF CANNABINOID AGONIST ON INHIBITORY AVOIDANCE MEMORY IN MALE RATS

Author(s)

MOSHFEGH A. | YARABI A.R. | TEHRANIFARD A. | DASTAN K. | Issue Writer Certificate

Keywords

CANNABINOIDSQ2

α-1Q2

ADRENERGICQ2

LEARNINGQ2

Abstract

Introduction: There are many similarities between memory impairment in patients suffering from Alzheimer and animals treated by CANNABINOIDS. The agonists of Cannabinoid receptors affect on a variety of memories and leanings. The present study aims to investigate the role of a-1-adrenergic receptors in central region of amygdala in state-dependent LEARNING induced by WIN55, 212-2 (cannabinoid agonist) in rats.Methods: Cannulae placement was performed bilaterally in the central amygdala region of male rats. The rats were trained in the avoidance LEARNING apparatus (step-down model). 24 hours after training, the memory was tested by measuring the lag time for stepping down the platform.Results: Injection of WIN55, 212-2 intra central amygdala (dose-dependent, 0.25, 0.5 mg/rat) post-training reduced lag time/latency for stepping down. Injection induced amnesia was reversed by pre-test administration of the same dose of WIN55, 212-2. It is called state-dependent LEARNING. Pre-test intra-central injection of a-1-adrenoceptor agonist, Phenylephrine (0.5, 0.25 mg/rat) improved post-training WIN55, 212-2 (0.5 mg/rat) intra central injection induced retrieval impairment. But intra injection of Prazosin (0.5 mg/rat) 2 minutes before injection of WIN55, 212-2 (0.5 mg/rat) on the testing day inhibited WIN55, 212-2 state-dependent LEARNING.Conclusion: The results suggest that a-1-adrenergic receptors in central region of amygdala are involved in LEARNING which dependent on the state induced by WIN55, 212-2.

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APA: Copy

MOSHFEGH, A., YARABI, A.R., TEHRANIFARD, A., & DASTAN, K.. (2015). INVOLVEMENT OF α-1-ADRENERGIC RECEPTORS IN CENTRAL REGION OF AMYGDALA AND THE EFFECTS OF CANNABINOID AGONIST ON INHIBITORY AVOIDANCE MEMORY IN MALE RATS. HORMOZGAN MEDICAL JOURNAL, 18(5), 397-409. SID. https://sid.ir/paper/60532/en

Vancouver: Copy

MOSHFEGH A., YARABI A.R., TEHRANIFARD A., DASTAN K.. INVOLVEMENT OF α-1-ADRENERGIC RECEPTORS IN CENTRAL REGION OF AMYGDALA AND THE EFFECTS OF CANNABINOID AGONIST ON INHIBITORY AVOIDANCE MEMORY IN MALE RATS. HORMOZGAN MEDICAL JOURNAL[Internet]. 2015;18(5):397-409. Available from: https://sid.ir/paper/60532/en

IEEE: Copy

A. MOSHFEGH, A.R. YARABI, A. TEHRANIFARD, and K. DASTAN, “INVOLVEMENT OF α-1-ADRENERGIC RECEPTORS IN CENTRAL REGION OF AMYGDALA AND THE EFFECTS OF CANNABINOID AGONIST ON INHIBITORY AVOIDANCE MEMORY IN MALE RATS,” HORMOZGAN MEDICAL JOURNAL, vol. 18, no. 5, pp. 397–409, 2015, [Online]. Available: https://sid.ir/paper/60532/en

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