THE EFFECT OF APIUM GRAVEO LENS ON DOXORUBICICIN-INDUCED TOXICITY IN H9C2 CARDIO MYOBLASTS

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MAHDIAN D.; HOSSEINI A.; RAKHSHANDEH H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Advances in Medical and Biomedical Research Year:2016 | Volume:24 | Issue:104 Page(s): 10-19

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Title

THE EFFECT OF APIUM GRAVEO LENS ON DOXORUBICICIN-INDUCED TOXICITY IN H9C2 CARDIO MYOBLASTS

Author(s)

MAHDIAN D. | HOSSEINI A. | RAKHSHANDEH H. | Issue Writer Certificate

Keywords

DOXORUBICINQ2

H9C2Q1

APOPTOSISQ2

APIUM GRAVE OLENSQ1

Abstract

Background and Objective: DOXORUBICIN is one of the most effective chemotherapeutic agents against solid tumors. DOXORUBICIN causes cardio-toxicity via production of free radicals and depletion of anti-oxidants. However, the use of anti-oxidants can decrease DOXORUBICIN-induced cardio-toxicity. APIUM GRAVE OLENS (celery) contains anti-oxidant compounds. Hence, this study was an attempt to figure out if it can protect heart cells against oxidative stress of DOXORUBICIN.Materials and Methods: The cells were incubated with different concentrations of APIUM GRAVE OLENS (celery) extract for 4 hours which continued in the presence of 5mM DOXORUBICIN for 24 hours. Cell viability and the apoptotic induction were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium (MTT) and propidium iodide (PI) staining assays, respectively.Results: Celery extract increased toxicity of DOXORUBICIN at a concentration of 125-500 mg/ml. Also APOPTOSIS was induced in the presence of DOXORUBICIN at a concentration of 250 and 500mg/ml.Conclusion: Results showed that celery has no toxicity effect on heart cells alone. However, this extract could not protect cells against DOXORUBICIN- induced cardio toxicity. A number of mechanisms may increase this effect such as augmentation of free radicals, increased drug delivery into the cells and expression of apoptotic proteins. Further research is needed to decide upon accuracy mechanism.

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APA: Copy

MAHDIAN, D., HOSSEINI, A., & RAKHSHANDEH, H.. (2016). THE EFFECT OF APIUM GRAVEO LENS ON DOXORUBICICIN-INDUCED TOXICITY IN H9C2 CARDIO MYOBLASTS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 24(104), 10-19. SID. https://sid.ir/paper/61137/en

Vancouver: Copy

MAHDIAN D., HOSSEINI A., RAKHSHANDEH H.. THE EFFECT OF APIUM GRAVEO LENS ON DOXORUBICICIN-INDUCED TOXICITY IN H9C2 CARDIO MYOBLASTS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2016;24(104):10-19. Available from: https://sid.ir/paper/61137/en

IEEE: Copy

D. MAHDIAN, A. HOSSEINI, and H. RAKHSHANDEH, “THE EFFECT OF APIUM GRAVEO LENS ON DOXORUBICICIN-INDUCED TOXICITY IN H9C2 CARDIO MYOBLASTS,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 24, no. 104, pp. 10–19, 2016, [Online]. Available: https://sid.ir/paper/61137/en

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