STUDY OF CORRELATION OF SURFACE PHOSPHOLIPIDS FATTY ACID COMPOSITION IN HIGH DENSITY LIPOPROTEIN WITH THE SEVERITY OF CORONARY ARTERY DISEASE AFTER ANGIOGRAPHY

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NOURI MOHAMMAD; DARABI MASOUD; RAHIMIPOUR ALI; RAHBANI M.; ASLANABADI N.; SHAKER M.; MAHDIZADEH A.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2009 | Volume:16 | Issue:65 Page(s): 13-21

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Title

STUDY OF CORRELATION OF SURFACE PHOSPHOLIPIDS FATTY ACID COMPOSITION IN HIGH DENSITY LIPOPROTEIN WITH THE SEVERITY OF CORONARY ARTERY DISEASE AFTER ANGIOGRAPHY

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Keywords

CORONARY ARTERY DISEASEQ3

FATTY ACIDSQ2

HIGH-DENSITY LIPOPROTEINQ3

Abstract

Background and Objective: The phospholipids fatty acid content of HIGH-DENSITY LIPOPROTEIN (HDL) has recently been found to be related to several important biological functions which may serve as a risk factor for CORONARY ARTERY DISEASE (CAD). The purpose of this study was to investigate whether fatty acid composition of HDL phospholipids correlates with the presence and severity of CORONARY ARTERY DISEASE.Materials and Methods: The study population included 117 patients with CORONARY ARTERY DISEASE which was approved by angiography. The severity of CAD was assessed by the number of arteries (1, 2 or 3) with more than 50% stenosis reported by angiography. The fatty acid composition of HDL phospholipids was determined by gas liquid chromatography. The independence of association between FATTY ACIDS and CAD were evaluated by multivariate analyses which included all of the variables associated with the severity of CAD in univariate analysis.Results: These analyses showed that the association of EPA (b=-0.23, P<0.01) and DHA (b =-0.17, P<0.05) with the severity of CAD was inversely and independently significant.Conclusion: Some kinds of polyunsaturated HDL fatty acid contents such as EPA and DHA (omega-3 FATTY ACIDS) have adverse association with severity of CAD.

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APA: Copy

NOURI, MOHAMMAD, DARABI, MASOUD, RAHIMIPOUR, ALI, RAHBANI, M., ASLANABADI, N., SHAKER, M., & MAHDIZADEH, A.. (2009). STUDY OF CORRELATION OF SURFACE PHOSPHOLIPIDS FATTY ACID COMPOSITION IN HIGH DENSITY LIPOPROTEIN WITH THE SEVERITY OF CORONARY ARTERY DISEASE AFTER ANGIOGRAPHY. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 16(65), 13-21. SID. https://sid.ir/paper/61544/en

Vancouver: Copy

NOURI MOHAMMAD, DARABI MASOUD, RAHIMIPOUR ALI, RAHBANI M., ASLANABADI N., SHAKER M., MAHDIZADEH A.. STUDY OF CORRELATION OF SURFACE PHOSPHOLIPIDS FATTY ACID COMPOSITION IN HIGH DENSITY LIPOPROTEIN WITH THE SEVERITY OF CORONARY ARTERY DISEASE AFTER ANGIOGRAPHY. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2009;16(65):13-21. Available from: https://sid.ir/paper/61544/en

IEEE: Copy

MOHAMMAD NOURI, MASOUD DARABI, ALI RAHIMIPOUR, M. RAHBANI, N. ASLANABADI, M. SHAKER, and A. MAHDIZADEH, “STUDY OF CORRELATION OF SURFACE PHOSPHOLIPIDS FATTY ACID COMPOSITION IN HIGH DENSITY LIPOPROTEIN WITH THE SEVERITY OF CORONARY ARTERY DISEASE AFTER ANGIOGRAPHY,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 16, no. 65, pp. 13–21, 2009, [Online]. Available: https://sid.ir/paper/61544/en

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