STUDY OF ANTIOXIDANT STATUS AND OXIDATIVE STRESS IN DIABETIC RATS TREATED WITH ROYAL JELLY

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GHANBARI E.; ANSARIAN A.; YOSEFZAEI F.; KHAZAEI M.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2017 | Volume:25 | Issue:111 Page(s): 82-93

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Title

STUDY OF ANTIOXIDANT STATUS AND OXIDATIVE STRESS IN DIABETIC RATS TREATED WITH ROYAL JELLY

Author(s)

GHANBARI E. | ANSARIAN A. | YOSEFZAEI F. | KHAZAEI M. | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

ROYAL JELLYQ2

OXIDATIVE STRESSQ2

LIPID PEROXIDATIONQ1

LIVERQ2

Abstract

Background and Objective: DIABETES MELLITUS is one of the most common metabolic disorders worldwide.Numerous natural compounds have been developed to treat DIABETES MELLITUS. ROYAL JELLY (RJ) has antioxidant and antidiabetic properties. This study was carried out to investigate the effects of RJ on antioxidant status, LIPID PEROXIDATION and LIVER tissue in diabetic rats.Materials and Methods: In this experimental study, 32 adult male Wistar rats (190-200 gr) were randomly divided into 4 groups including control, ROYAL JELLY, diabetic and diabetic treated with ROYAL JELLY. Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg) and ROYAL JELLY (100 mg/kg) was gavaged for 42 days. At the end of our study, serum levels of malondialdehyde, total antioxidant capacity (TCA) and superoxide dismutase and glutathione peroxidase activities were determined spectrophotometrically, while the rat’s LIVERs were isolated for histological study.Results: Consumption of RJ showed a significant decrease in malondialdehyde serum levels (P=0.007) and a significant increase in total antioxidant capacity, superoxide dismutase (P=0.0019) and glutathione peroxidase activities in the RJ treated diabetic rats compared to diabetic rats (P=0.003). Administration of ROYAL JELLY improved LIVER histological states.Conclusion: RJ increased antioxidant power and prevented the occurrence of histopathological changes resulting from diabetes in rats.

Cites

Response of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase enzymes to aerobic exercise and royal jelly in multiple sclerosis patients

References

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APA: Copy

GHANBARI, E., ANSARIAN, A., YOSEFZAEI, F., & KHAZAEI, M.. (2017). STUDY OF ANTIOXIDANT STATUS AND OXIDATIVE STRESS IN DIABETIC RATS TREATED WITH ROYAL JELLY. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 25(111), 82-93. SID. https://sid.ir/paper/61582/en

Vancouver: Copy

GHANBARI E., ANSARIAN A., YOSEFZAEI F., KHAZAEI M.. STUDY OF ANTIOXIDANT STATUS AND OXIDATIVE STRESS IN DIABETIC RATS TREATED WITH ROYAL JELLY. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2017;25(111):82-93. Available from: https://sid.ir/paper/61582/en

IEEE: Copy

E. GHANBARI, A. ANSARIAN, F. YOSEFZAEI, and M. KHAZAEI, “STUDY OF ANTIOXIDANT STATUS AND OXIDATIVE STRESS IN DIABETIC RATS TREATED WITH ROYAL JELLY,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 25, no. 111, pp. 82–93, 2017, [Online]. Available: https://sid.ir/paper/61582/en

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