EVALUATION OF THE EFFECT OF METHYLXANTINE DERIVATIVES ON PREVENTION OF POSTDURAL PUNCTURE HEADACHE IN ELECTIVE CESAREAN SECTION

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SADEGHI SEYYED EBRAHIM; NABI RAHIMIAN MOHAMMAD; ATTARI MAHDI; ZAREI HUSSAIN; HASAN ZAHRAEE SEYYED MOHAMMAD; HUSSAIN ZAHRAEE SEYYED ALI

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2013 | Volume:35 | Issue:81 Page(s): 6-11

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Title

EVALUATION OF THE EFFECT OF METHYLXANTINE DERIVATIVES ON PREVENTION OF POSTDURAL PUNCTURE HEADACHE IN ELECTIVE CESAREAN SECTION

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Keywords

POST DURAL PUNCTURE HEADACHEQ2

PREVENTIONQ2

AMINOPHYLLINEQ2

Abstract

Introduction: Postdural puncture headache (PDPH) is a common problem after neuroaxial block. Several policies have been forwarded for the treatment of PDPH including methyl xanthine drugs. It seems that these drugs induce cerebral vasoconstriction and thus decreasing PDPH severity via adenosine receptors.This study aimed to evaluate the effect of methyl xanthine drugs on PREVENTION of PDPH.Materials and methods: In a double blind randomized clinical trial, we evaluated 180 patients in three groups (n=60) undergoing spinal anesthesia for elective cesarean section in Motahhari hospital of Marvdasht-Fars province during 2011.After umbilical cord clamping, in first group AMINOPHYLLINE was injected slowly intravenously (1.5 mg/kg body weight).In placebo group (n=60) normal saline was injected intravenously: In the third group after one dose AMINOPHYLLINE intravenously, the patients received one tablet theophylline each 8 hours for 3 days.At the 1st, 4th, 24th and 48th hour after surgery, incidence of PDPH in each group evaluated.Results: The incidence of PDPH was significantly lower in first (n=2) and third group (n=2) compared with placebo group (n=8) at 24th hour post operation. At 48th hour post operation9, 8 and 19 patients suffered from PDPH in1st, 3rd and 2nd (placebo) group respectively, which was statistically significant. The incidence of PDPH in 3rd group was not less than the 1st group.Conclusion: This study shows that intravenous administration of AMINOPHYLLINE significantly reduces the incidence of PDPH in cesarean section and we can use this regimen for PREVENTION of PDPH.

Cites

EFFECT OF PROPHYLACTIC SINGLE DOSE OF DESOXY CORTICOSTERONE ACETATE ON POST DURAL PUNCTURE HEADACHE AFTER SPINAL ANESTHESIA

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APA: Copy

SADEGHI, SEYYED EBRAHIM, NABI RAHIMIAN, MOHAMMAD, ATTARI, MAHDI, ZAREI, HUSSAIN, HASAN ZAHRAEE, SEYYED MOHAMMAD, & HUSSAIN ZAHRAEE, SEYYED ALI. (2013). EVALUATION OF THE EFFECT OF METHYLXANTINE DERIVATIVES ON PREVENTION OF POSTDURAL PUNCTURE HEADACHE IN ELECTIVE CESAREAN SECTION. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 35(81), 6-11. SID. https://sid.ir/paper/63390/en

Vancouver: Copy

SADEGHI SEYYED EBRAHIM, NABI RAHIMIAN MOHAMMAD, ATTARI MAHDI, ZAREI HUSSAIN, HASAN ZAHRAEE SEYYED MOHAMMAD, HUSSAIN ZAHRAEE SEYYED ALI. EVALUATION OF THE EFFECT OF METHYLXANTINE DERIVATIVES ON PREVENTION OF POSTDURAL PUNCTURE HEADACHE IN ELECTIVE CESAREAN SECTION. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2013;35(81):6-11. Available from: https://sid.ir/paper/63390/en

IEEE: Copy

SEYYED EBRAHIM SADEGHI, MOHAMMAD NABI RAHIMIAN, MAHDI ATTARI, HUSSAIN ZAREI, SEYYED MOHAMMAD HASAN ZAHRAEE, and SEYYED ALI HUSSAIN ZAHRAEE, “EVALUATION OF THE EFFECT OF METHYLXANTINE DERIVATIVES ON PREVENTION OF POSTDURAL PUNCTURE HEADACHE IN ELECTIVE CESAREAN SECTION,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 35, no. 81, pp. 6–11, 2013, [Online]. Available: https://sid.ir/paper/63390/en

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