THE EFFECTIVENESS OF HOLOPRIDOL ON EYE DEVELOPMENT IN MOUSE EMBRYO

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ZIRAK JAVANMARD M.; SADRKHANLOU R.A.

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Journal: Studies in Medical Sciences Year:2002 | Volume:13 | Issue:1 Page(s): 25-32

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Information Journal Paper

Title

THE EFFECTIVENESS OF HOLOPRIDOL ON EYE DEVELOPMENT IN MOUSE EMBRYO

Author(s)

ZIRAK JAVANMARD M. | SADRKHANLOU R.A. | Issue Writer Certificate

Keywords

HALOPERIDOLQ4

NEURAL TUBEQ4

MOUSE EMBRYOQ4

Abstract

Introduction: Antipsychotic and sedative drugs such as diazepam, lithium and HALOPERIDOL have teratogenic effects. In regard to the fact that primary optic vesicle is derivate form of NEURAL TUBE and teratogenic effect of HALOPERIDOL is generally related to nerve system. In this study, the relationship between the use of these drugs and their side effects in the optic system was assessed. Materials &. Methods: In this study the effectiveness of HALOPERIDOL on optic vesicle was assessed in two groups of animals. In the first group, 5 mg and in the second group 10 mg/kg of drug was administered. The embryos were taken out from uterus and processed using paraffin embedded method. The slides were studied under light microscope. Result: The results were indicated that there was a significant relation between applying HALOPERIDOL and eye anomalies such as defect in formation of lense, retina and optic nerve. Discussion: The development of the eye appears as a pair of shallow grooves on the forebrain in our study. The anomalies of the eye such as defect in formation of lens, retina and optic nerve were observed. It appears that injection of optic vesicle has impact on cell division and thus resulting cell death, therefore vesicle was abnormal.

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APA: Copy

ZIRAK JAVANMARD, M., & SADRKHANLOU, R.A.. (2002). THE EFFECTIVENESS OF HOLOPRIDOL ON EYE DEVELOPMENT IN MOUSE EMBRYO. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 13(1), 25-32. SID. https://sid.ir/paper/63932/en

Vancouver: Copy

ZIRAK JAVANMARD M., SADRKHANLOU R.A.. THE EFFECTIVENESS OF HOLOPRIDOL ON EYE DEVELOPMENT IN MOUSE EMBRYO. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2002;13(1):25-32. Available from: https://sid.ir/paper/63932/en

IEEE: Copy

M. ZIRAK JAVANMARD, and R.A. SADRKHANLOU, “THE EFFECTIVENESS OF HOLOPRIDOL ON EYE DEVELOPMENT IN MOUSE EMBRYO,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 13, no. 1, pp. 25–32, 2002, [Online]. Available: https://sid.ir/paper/63932/en

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