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Title

ESTROGEN PROVIDES NEUROPROTECTION AGAINST BRAIN EDEMA AND BLOOD BRAIN BARRIER DISRUPTION THROUGH BOTH ESTROGEN RECEPTORS α AND β FOLLOWING TRAUMATIC BRAIN INJURY

Pages

  138-144

Abstract

 Objective(s): Estrogen (E2) has neuroprotective effects on BLOOD-BRAIN-BARRIER (BBB) after traumatic brain injury (TBI). In order to investigate the roles of estrogen receptors (ERs) in these effects, ER-a antagonist (MPP) and, ER-b antagonist (PHTPP), or non-selective estrogen receptors antagonist (ICI 182780) were administered.Materials and Methods: Ovariectomized rats were divided into 10 groups, as follows: Sham, TBI, E2, oil, MPP+E2, PHTPP+E2, MPP+PHTPP+E2, ICI+E2, MPP, and DMSO. E2 (33.3 mg/Kg) or oil were administered 30 min after TBI. 1 dose (150 mg/Kg) of each of MPP, PHTPP, and (4 mg/kg) ICI182780 was injected two times, 24 hr apart, before TBI and estrogen treatment. BBB disruption (Evans blue content) and BRAIN EDEMA (brain water content) evaluated 5 hr and 24 hr after the TBI were evaluated, respectively.Results: The results showed that E2 reduced BRAIN EDEMA after TBI compared to vehicle (P<0.01). The BRAIN EDEMA in the MPP+E2 and PHTPP+E2 groups decreased compared to the vehicle (P<0.001). There was no significant difference in MPP+PHTPP+E2 and ICI+E2 compared to TBI. This parameter in MPP was similar to vehicle. Evans blue content in E2 group was lower than vehicle (P<0.05).The inhibitory effect of E2 on Evans blue was not reduced by MPP+E2 and PHTPP+E2 groups, but decreased by treatment with MPP+PHTPP or ICI. MPP had no effect on Evans blue content.Conclusion: A combined administration of MPP and PHTPP or ICI inhibited the E2-induced decrease in BRAIN EDEMA and BBB disruption; this may suggest that these effects were mediated via both receptors.

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    APA: Copy

    NADERI, VIDA, KHAKSARI, MOHAMMAD, ABBASI, REZA, & MAGHOOL, FATEMEH. (2015). ESTROGEN PROVIDES NEUROPROTECTION AGAINST BRAIN EDEMA AND BLOOD BRAIN BARRIER DISRUPTION THROUGH BOTH ESTROGEN RECEPTORS α AND β FOLLOWING TRAUMATIC BRAIN INJURY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(2), 138-144. SID. https://sid.ir/paper/650890/en

    Vancouver: Copy

    NADERI VIDA, KHAKSARI MOHAMMAD, ABBASI REZA, MAGHOOL FATEMEH. ESTROGEN PROVIDES NEUROPROTECTION AGAINST BRAIN EDEMA AND BLOOD BRAIN BARRIER DISRUPTION THROUGH BOTH ESTROGEN RECEPTORS α AND β FOLLOWING TRAUMATIC BRAIN INJURY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(2):138-144. Available from: https://sid.ir/paper/650890/en

    IEEE: Copy

    VIDA NADERI, MOHAMMAD KHAKSARI, REZA ABBASI, and FATEMEH MAGHOOL, “ESTROGEN PROVIDES NEUROPROTECTION AGAINST BRAIN EDEMA AND BLOOD BRAIN BARRIER DISRUPTION THROUGH BOTH ESTROGEN RECEPTORS α AND β FOLLOWING TRAUMATIC BRAIN INJURY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 2, pp. 138–144, 2015, [Online]. Available: https://sid.ir/paper/650890/en

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