RELATIONSHIP BETWEEN FAS RS1800682 GENE POLYMORPHISM AND SUSCEPTIBILITY TO POLYCYSTIC OVARY SYNDROME

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HEIDARPANAH SAMIRA; KOHAN LEILA; HASHEMI SEYEDEHSARA

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2017 | Volume:19 | Issue:10 (115) Page(s): 9-16

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Title

RELATIONSHIP BETWEEN FAS RS1800682 GENE POLYMORPHISM AND SUSCEPTIBILITY TO POLYCYSTIC OVARY SYNDROME

Author(s)

HEIDARPANAH SAMIRA | KOHAN LEILA | HASHEMI SEYEDEHSARA | Issue Writer Certificate

Keywords

FASQ1

POLYCYSTIC OVARY SYNDROMEQ2

POLYMORPHISMQ2

Abstract

Background: POLYCYSTIC OVARY SYNDROME (PCOS) is the most common endocrine aberration in women. PCOS is characterized by ovarian hyperandrogenism and anovulation resulted from a disorder of follicular maturation. Apoptosis is a regulatory mechanism for oocyte maturation and survival. Several studies have shown a possible role of FAS in ovarian apoptosis. The present study is the first investigation to examine the possible association of FAS rs1800682gene POLYMORPHISM with PCOS risk in Iranian women.Materials and Methods: This case-control study was conducted on 251 patients with PCOS and 213 healthy control women. The FAS rs1800682 gene POLYMORPHISM genotypes were analyzed using the Tetra-ARMS-PCR method. Also, logistic regression analysis was used to investigate the association between genotypes and PCOS risk.Results: There was a significant association between A allele and susceptibility to PCOS (OR =1.4, %95CI=1.08-1.83, p=0.011). Moreover, in the recessive genetic model for A allele, the AA genotype increased the risk of PCOS after adjusting age and body mass index (OR=1.6, %95CI=1.02- 2.51, p=0.041).Conclusion: For the first time, this study showed that FAS rs1800682 POLYMORPHISM is associated with PCOS risk in Iranian women and the A allele may act as a recessive allele for increasing the risk of PCOS.

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APA: Copy

HEIDARPANAH, SAMIRA, KOHAN, LEILA, & HASHEMI, SEYEDEHSARA. (2017). RELATIONSHIP BETWEEN FAS RS1800682 GENE POLYMORPHISM AND SUSCEPTIBILITY TO POLYCYSTIC OVARY SYNDROME. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(10 (115)), 9-16. SID. https://sid.ir/paper/68921/en

Vancouver: Copy

HEIDARPANAH SAMIRA, KOHAN LEILA, HASHEMI SEYEDEHSARA. RELATIONSHIP BETWEEN FAS RS1800682 GENE POLYMORPHISM AND SUSCEPTIBILITY TO POLYCYSTIC OVARY SYNDROME. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;19(10 (115)):9-16. Available from: https://sid.ir/paper/68921/en

IEEE: Copy

SAMIRA HEIDARPANAH, LEILA KOHAN, and SEYEDEHSARA HASHEMI, “RELATIONSHIP BETWEEN FAS RS1800682 GENE POLYMORPHISM AND SUSCEPTIBILITY TO POLYCYSTIC OVARY SYNDROME,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 10 (115), pp. 9–16, 2017, [Online]. Available: https://sid.ir/paper/68921/en

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