مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Generation of motor neurons from human amygdala-derived neural stem-like cells

Pages

  1155-1160

Abstract

 Objective(s): Among several cell sources, adult human neural stem/progenitor cells (hNS/PCs) have been considered outstanding cells for performing mechanistic studies in in vitro and in vivo models of neurological disorders as well as for potential utility in cell-based therapeutic approaches. Previous studies addressed the isolation and culture of hNS/PCs from human neocortical and hippocampal tissues. However, little data are available on hNS/PCs obtained from the adult human amygdala. Materials and Methods: The present study explored the capacity of the amygdala harvested from resected Brain tissues of patients with medically refractory epilepsy to generate neurosphere-like bodies and Motor neuron-like cells. Results: Although the proliferation process was slow, a considerable amount of cells was obtained after the 3rd passage. In addition, the cells could generate Motor neuron-like cells under appropriate culture conditions. Conclusion: Isolation and culture of these cells enable us to improve our knowledge of the role of the amygdala in some neurological and psychological disorders and provide a novel source for therapeutic cell transplantation.

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    APA: Copy

    GHASEMI, SEPIDEH, ALIGHOLI, HADI, Koulivand, Pir Hossein, JAFARIAN, MARYAM, HOSSEINI RAVANDI, HASSAN, KHALEGHI GHADIRI, MARYAM, & GORJI, ALI. (2018). Generation of motor neurons from human amygdala-derived neural stem-like cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(11), 1155-1160. SID. https://sid.ir/paper/721999/en

    Vancouver: Copy

    GHASEMI SEPIDEH, ALIGHOLI HADI, Koulivand Pir Hossein, JAFARIAN MARYAM, HOSSEINI RAVANDI HASSAN, KHALEGHI GHADIRI MARYAM, GORJI ALI. Generation of motor neurons from human amygdala-derived neural stem-like cells. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(11):1155-1160. Available from: https://sid.ir/paper/721999/en

    IEEE: Copy

    SEPIDEH GHASEMI, HADI ALIGHOLI, Pir Hossein Koulivand, MARYAM JAFARIAN, HASSAN HOSSEINI RAVANDI, MARYAM KHALEGHI GHADIRI, and ALI GORJI, “Generation of motor neurons from human amygdala-derived neural stem-like cells,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 11, pp. 1155–1160, 2018, [Online]. Available: https://sid.ir/paper/721999/en

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