COMPARISON BETWEEN THE EFFECT OF ETOMOXIR AND RANOLAZINE ON ISCHEMIA-REPERFUSION INDUCED CARDIAC ARRHYTHMIAS IN ISOLATED RAT HEART

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NAJAFI MOSLEM; ETERAF OSKOUEI T.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2008 | Volume:9 | Issue:5 (40) Page(s): 7-13

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Title

COMPARISON BETWEEN THE EFFECT OF ETOMOXIR AND RANOLAZINE ON ISCHEMIA-REPERFUSION INDUCED CARDIAC ARRHYTHMIAS IN ISOLATED RAT HEART

Author(s)

NAJAFI MOSLEM | ETERAF OSKOUEI T. | Issue Writer Certificate

Keywords

ETOMOXIRQ3

RANOLAZINEQ3

ISCHEMIA/REPERFUSIONQ3

ARRHYTHMIASQ3

ISOLATED HEARTQ3

RATQ2

Abstract

Background and Objectives: ETOMOXIR and RANOLAZINE have been considered as two new agents with various effects of metabolic pathways to treatment of ischemic heart diseases. In the present study, their effects on ischemia-reperfusion (I/R) induced ARRHYTHMIAS were studied and compared together in isolated RAT heart. Methods: In this experimental study, male Sprague-Dawley RATs (270-330g) were anaesthetized by sodium pentobarbital (50mg/kg, ip) then their hearts were immediately isolated and mounted on a non-recirculating langendorff apparatus at constant pressure. The hearts were divided into three groups randomly (n=10 RATs in each group) including control, ETOMOXIR treated and RANOLAZINE treated groups. In the control group, the hearts were perfused by a modified Krebs-Henseleite solution at stabilization, 30min regional ischemia and 30min reperfusion while in the test groups; they were perfused by enriched Krebs solution with ETOMOXIR (1mM) or RANOLAZINE (20mM) from 10min before ischemia to end of reperfusion. ARRHYTHMIAS events were assessed according to the Lambeth convention.Findings: In the ischemic phase, the number of ventricular ectopic beats (VEBs) in the control group was 667±116 while perfusion of RANOLAZINE and ETOMOXIR reduced it to 33±16 (p<0.001) and 501±165, respectively. The number of ischemic ventricular tachycardia (VT) was also lowered by RANOLAZINE and ETOMOXIR from 280±50 (control) to 0 (p<0.001) and 146±50, respectively. In addition, both agents significantly decreased the incidence of ischemic VT. The number of reperfusion VEBs and VT were lowered by RANOLAZINE (p<0.01 and p<0.001, respectively). RANOLAZINE also reduced the incidence of total ventricular fibrillation (VF) and the time spent for reversible VF from 63% and 218±69sec (control) to 0% (p<0.05) and 0 sec (p<0.01), respectively. At the same time, ETOMOXIR in a lower level showed significant antiarrhythmic effects. Comparison between the antiarrhythmic effects of the agents did not show statistically significant difference.Conclusion: The results of this study showed protective effects of ETOMOXIR and RANOLAZINE against I/R induced ARRHYTHMIAS without any significant difference between the agents. It seems that beneficial effect of ETOMOXIR and RANOLAZINE likely is secondary to indirect increasing in glucose oxidation during I/R.

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APA: Copy

NAJAFI, MOSLEM, & ETERAF OSKOUEI, T.. (2008). COMPARISON BETWEEN THE EFFECT OF ETOMOXIR AND RANOLAZINE ON ISCHEMIA-REPERFUSION INDUCED CARDIAC ARRHYTHMIAS IN ISOLATED RAT HEART. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 9(5 (40)), 7-13. SID. https://sid.ir/paper/73022/en

Vancouver: Copy

NAJAFI MOSLEM, ETERAF OSKOUEI T.. COMPARISON BETWEEN THE EFFECT OF ETOMOXIR AND RANOLAZINE ON ISCHEMIA-REPERFUSION INDUCED CARDIAC ARRHYTHMIAS IN ISOLATED RAT HEART. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2008;9(5 (40)):7-13. Available from: https://sid.ir/paper/73022/en

IEEE: Copy

MOSLEM NAJAFI, and T. ETERAF OSKOUEI, “COMPARISON BETWEEN THE EFFECT OF ETOMOXIR AND RANOLAZINE ON ISCHEMIA-REPERFUSION INDUCED CARDIAC ARRHYTHMIAS IN ISOLATED RAT HEART,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 9, no. 5 (40), pp. 7–13, 2008, [Online]. Available: https://sid.ir/paper/73022/en

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