EVALUATION OF MUTATIONS IN EXONS 7 AND 8 OF TP53 GENE IN BREAST CANCER PATIENTS FROM AZARBAIJAN

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POULADI N.; HOSSEINPOUR FEIZI M.A.; KHANI H.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2016 | Volume:18 | Issue:2 Page(s): 19-25

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Title

EVALUATION OF MUTATIONS IN EXONS 7 AND 8 OF TP53 GENE IN BREAST CANCER PATIENTS FROM AZARBAIJAN

Author(s)

POULADI N. | HOSSEINPOUR FEIZI M.A. | KHANI H. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

MUTATIONQ1

TP53 GENE.Q2

Abstract

BACKGROUND AND OBJECTIVE: BREAST CANCER is the most common type of malignancy in women, and TP53 tumor-suppressor gene is one of the most commonly transformed genes in human cancers. Accurate assessment of TP53 GENE.em style="font-style:inherit;color:#ff0078"> MUTATIONs in cancer patients can play an important role in diagnosis, prognosis, or treatment. This study aimed to identify MUTATIONs of this gene in BREAST CANCER patients.METHODS: In this descriptive study, 102 tumor samples were obtained from female BREAST CANCER patients from Azarbaijan, Iran. All the participants were referred to hospitals of Tabriz during 2007-2009, and their DNA was extracted by Proteinase K. TP53 GENE.em style="font-style:inherit;color:#ff0078"> MUTATIONs in exons 7 and 8 and intron 7 were investigated using polymerase chain reaction technique and direct sequencing.FINDINGS: Seven (6.86%) cases of MUTATION and 14 (13.72%) cases of polymorphisms were identified. MUTATIONs (CGG → CAG) at codon 248 (in two cases) and (CTG → CCG) at codon 257 in exon 7 and G>T MUTATION in the first nucleotide of intron 7 were observed. In exon 8, GTG>ATG MUTATION at codon 272, CCT>TCT MUTATION at codon 278, and three nucleotide deletion at codon 262 were identified.CONCLUSION: The results of this study showed a different pattern of TP53 GENE.em style="font-style:inherit;color:#ff0078"> MUTATION in female BREAST CANCER patients. Further studies could specify the role of TP53 MUTATIONs in the progression of BREAST CANCER.

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APA: Copy

POULADI, N., HOSSEINPOUR FEIZI, M.A., & KHANI, H.. (2016). EVALUATION OF MUTATIONS IN EXONS 7 AND 8 OF TP53 GENE IN BREAST CANCER PATIENTS FROM AZARBAIJAN. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 18(2), 19-25. SID. https://sid.ir/paper/73070/en

Vancouver: Copy

POULADI N., HOSSEINPOUR FEIZI M.A., KHANI H.. EVALUATION OF MUTATIONS IN EXONS 7 AND 8 OF TP53 GENE IN BREAST CANCER PATIENTS FROM AZARBAIJAN. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2016;18(2):19-25. Available from: https://sid.ir/paper/73070/en

IEEE: Copy

N. POULADI, M.A. HOSSEINPOUR FEIZI, and H. KHANI, “EVALUATION OF MUTATIONS IN EXONS 7 AND 8 OF TP53 GENE IN BREAST CANCER PATIENTS FROM AZARBAIJAN,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 18, no. 2, pp. 19–25, 2016, [Online]. Available: https://sid.ir/paper/73070/en

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