DETECTION OF MUTATIONS WITHIN EXONS 5 TO 8 OF THE TP53 GENE AMONG AZERI PATIENTS WITH SPORADIC THYROID CARCINOMA

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POULADI NASSER; HOSSEINPOUR FEIZI MOHAMMADALI

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Journal: Journal of Sabzevar University of Medical Sciences Year:2018 | Volume:25 | Issue:3 Page(s): 399-407

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Title

DETECTION OF MUTATIONS WITHIN EXONS 5 TO 8 OF THE TP53 GENE AMONG AZERI PATIENTS WITH SPORADIC THYROID CARCINOMA

Author(s)

POULADI NASSER | HOSSEINPOUR FEIZI MOHAMMADALI | Issue Writer Certificate

Keywords

MUTATIONQ2

P53 GENEQ2

THYROID CANCERQ1

Abstract

Background: THYROID CANCER is the most common malignant endocrine tumor, and the incidence was rising worldwide over the last three decades. TP53 is one of the most important tumor suppressor genes in the genome, and its MUTATIONs are found in approximately 50% of human cancers. It plays pivotal roles in the regulation of cell cycle arrest and apoptosis. The aim of this study was to analyze TP53 gene MUTATIONs among THYROID CANCER patients in East Azerbaijan.Material and Methods 40 tumor samples have been collected from THYROID CANCER patients from Tabriz hospitals between 2007-2009. DNA was extracted by Proteinase K– Iso propanol method and then the MUTATIONs in P53 GENE from exon 5 to exon 8 were detected by Polymarase Chain Reactions (PCR) and direct sequencing techniques.Results Alterations in the P53 GENE were detected in 12.5% of the patients, including single nucleotide polymorphisms and MUTATIONs, including codon 216 (GTG>GTA), codon 215 (AGT>ATT) and codon 273 (CGT>CAT) MUTATIONs (each MUTATION in one of the cases) and two linked polymorphisms 14181C>T and 14201T>G (in two cases).Conclusion This result helps us to clarify p53 MUTATION status among Azerbaijani THYROID CANCER patients.

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APA: Copy

POULADI, NASSER, & HOSSEINPOUR FEIZI, MOHAMMADALI. (2018). DETECTION OF MUTATIONS WITHIN EXONS 5 TO 8 OF THE TP53 GENE AMONG AZERI PATIENTS WITH SPORADIC THYROID CARCINOMA. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(3 ), 399-407. SID. https://sid.ir/paper/81907/en

Vancouver: Copy

POULADI NASSER, HOSSEINPOUR FEIZI MOHAMMADALI. DETECTION OF MUTATIONS WITHIN EXONS 5 TO 8 OF THE TP53 GENE AMONG AZERI PATIENTS WITH SPORADIC THYROID CARCINOMA. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(3 ):399-407. Available from: https://sid.ir/paper/81907/en

IEEE: Copy

NASSER POULADI, and MOHAMMADALI HOSSEINPOUR FEIZI, “DETECTION OF MUTATIONS WITHIN EXONS 5 TO 8 OF THE TP53 GENE AMONG AZERI PATIENTS WITH SPORADIC THYROID CARCINOMA,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 3 , pp. 399–407, 2018, [Online]. Available: https://sid.ir/paper/81907/en

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