EXPRESSION OF P53, P27KIP1 AND KI-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL; 2000-2006)

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SHAFIGH E.; ABD ALAZIMI Y.; SHAFAEI SH.; HAJ AHMADI MAHMOUD

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Journal: Journal of Babol University of Medical Sciences Year:2007 | Volume:9 | Issue:4 (39) Page(s): 7-14

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Title

EXPRESSION OF P53, P27KIP1 AND KI-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL; 2000-2006)

Author(s)

SHAFIGH E. | ABD ALAZIMI Y. | SHAFAEI SH. | HAJ AHMADI MAHMOUD | Issue Writer Certificate

Keywords

GASTRIC CANCERQ2

P53Q3

P27Q3

KI-67Q3

IMMUNOHISTOCHEMISTRYQ2

Abstract

BACKGROUND AND OBJECTIVE: Different studies have reported different results for expression of cell-cycle regulator genes, P53 and P27kip1, and proliferation marker KI-67 in GASTRIC CANCER and their correlation with clinicohistopathologic parameters and outcome. The aim of this study was to study the expression rate of P53, P27Kip1, KI-67 and their correlation with histopathological features and subsequently biological behavior in GASTRIC CANCER.METHODS: In this experimental (laboratory) study, 58 paraffin-embedded blocks from patients who underwent gastrectomy were stained by hematoxylin-eosin and then IMMUNOHISTOCHEMISTRY against P53, P27kip1 and KI-67. The statistical associations between clinicopathological parameters and immunohistochemical results were tested by Chi- Square and Fisher's- exact test using SPSS. FINDINGS: Male: female=2.86:1; median age= 60, antral location (27 cases), ulcerating macroscopic appearance (29 cases), intestinal (40 cases) and infiltrative type (48 cases) were the most frequent findings. Histological grade G1 (differentiated, 29 cases) and T3 + T4 stages (49 cases) were the most frequent. Number of cases with lymph node metastasis, vascular and neural invasion was 41, 49 and 47, respectively. Expression rate of P53, P27Kip1 and KI-67 were 56.9%, 56.9% and 75.9%, respectively. There was only a significant correlation between expression of P53 and KI-67 (p= 0.028, r=0.323).CONCLUSION: According to the results, studying the expression of P53, P27Kip1 and KI-67 markers alone do not have diagnostic value in predicting the biological behavior of GASTRIC CANCER.

Cites

IMMUNOHISTOCHEMICAL ASSESSMENT OF ER AND PR STATUS IN TISSUE TUMORS OF BREAST CANCER PATIENTS AND THEIR RELATION WITH PROLIFERATION AND TUMOR GRADE

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APA: Copy

SHAFIGH, E., ABD ALAZIMI, Y., SHAFAEI, SH., & HAJ AHMADI, MAHMOUD. (2007). EXPRESSION OF P53, P27^{KIP1 AND KI-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL; 2000-2006). JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 9(4 (39)), 7-14. SID. https://sid.ir/paper/73421/en}

Vancouver: Copy

SHAFIGH E., ABD ALAZIMI Y., SHAFAEI SH., HAJ AHMADI MAHMOUD. EXPRESSION OF P53, P27^{KIP1 AND KI-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL; 2000-2006). JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2007;9(4 (39)):7-14. Available from: https://sid.ir/paper/73421/en}

IEEE: Copy

E. SHAFIGH, Y. ABD ALAZIMI, SH. SHAFAEI, and MAHMOUD HAJ AHMADI, “EXPRESSION OF P53, P27^{KIP1 AND KI-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL; 2000-2006),” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 9, no. 4 (39), pp. 7–14, 2007, [Online]. Available: https://sid.ir/paper/73421/en}

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