INVOLVEMENT OF OPIOIDERGIC AND SEROTONINERGIC SYSTEMS IN THE ANTI-NOCICEPTIVE EFFECT OF TANACETUM PARTHENIUM

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FEREYDOUNI MASOUD; ETEMADI L.

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:2 Page(s): 115-120

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Information Journal Paper

Title

INVOLVEMENT OF OPIOIDERGIC AND SEROTONINERGIC SYSTEMS IN THE ANTI-NOCICEPTIVE EFFECT OF TANACETUM PARTHENIUM

Author(s)

FEREYDOUNI MASOUD | ETEMADI L. | Issue Writer Certificate

Keywords

TANACETUM PARTHENIUMQ4

OPIOIDERGIC SYSTEMQ3

SERTONINERGIC SYSTEMQ3

α -ADRENERGIC SYSTEMQ3

FORMALIN TESTQ3

MICEQ3

Abstract

Introduction: Feverfew (Tanacetumparthenium) (T.p.) is widely used in folk medicine to treat many diseases. We have reported the analgesic effect of T.p. flowers and leaves previously. The present study was designed to find the mechanisms underlying the anti-nociceptive effect of the aqueous extract of T.p. flower. Methods: Based on our previous study, the dose of 50 mg/kg Lp. of the T.p. aqueous extract has a potent analgesic effect on MICE (NMRI) (20±2g) in FORMALIN TEST. The same dose was used in the present study. Here, we studied the roles of opioidergic, serotoninergic and a-adrenergic systems in the anti-nociceptive effect of the T.p. extract. 15 min before the administration of the extract, animals were pretreated with drugs, including opioid antagonist naloxane (5mg/kg, i.p.), serotoninergic antagonist cyproheptadine (4 mg/kg, i.p.) and a-adrenergic antagonist phentolamine (20 mg/kg, i.p.) separately (n³6 in each group). Saline and the T.p. extract were used as controls. Results: Pretreatment with naloxane increased the pain sensation in the neurogenic phase of FORMALIN TEST compared to the control (p<0.001). Pretreatment with cyproheptadine increased the sensation of pain in both early and late phases (p<0.05). Inhibition of a-adrenergic system was not able to attenuate the anti-nociceptive effect of the extract. Conclusion: These results propose the involvement of sertoninergic and OPIOIDERGIC SYSTEMs in the anti-nociceptive effect of the T.p. extract.

Cites

THE EFFECT OF HYDROALCHOHOLIC EXTRACT OF HYPERICUM SCABRUM ON MORPHINE WITHDRAWAL SYMPTOMS IN ADULT MALE MICE

References

ANALGESIC EFFECT OF FLOWER AND LEAF EXTRACTS OF TANACETUM PARTHENIUM USING FORMALIN TEST IN MICE

Cite

APA: Copy

FEREYDOUNI, MASOUD, & ETEMADI, L.. (2008). INVOLVEMENT OF OPIOIDERGIC AND SEROTONINERGIC SYSTEMS IN THE ANTI-NOCICEPTIVE EFFECT OF TANACETUM PARTHENIUM. PHYSIOLOGY AND PHARMACOLOGY, 12(2), 115-120. SID. https://sid.ir/paper/75013/en

Vancouver: Copy

FEREYDOUNI MASOUD, ETEMADI L.. INVOLVEMENT OF OPIOIDERGIC AND SEROTONINERGIC SYSTEMS IN THE ANTI-NOCICEPTIVE EFFECT OF TANACETUM PARTHENIUM. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(2):115-120. Available from: https://sid.ir/paper/75013/en

IEEE: Copy

MASOUD FEREYDOUNI, and L. ETEMADI, “INVOLVEMENT OF OPIOIDERGIC AND SEROTONINERGIC SYSTEMS IN THE ANTI-NOCICEPTIVE EFFECT OF TANACETUM PARTHENIUM,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 2, pp. 115–120, 2008, [Online]. Available: https://sid.ir/paper/75013/en

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