THE EFFECT OF HYDROALCHOHOLIC EXTRACT OF HYPERICUM SCABRUM ON MORPHINE WITHDRAWAL SYMPTOMS IN ADULT MALE MICE

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AHMADI RAMESH; PISHGHADAM SAEEDE; MIRALI AMIN

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2014 | Volume:24 | Issue:3 Page(s): 143-147

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Title

THE EFFECT OF HYDROALCHOHOLIC EXTRACT OF HYPERICUM SCABRUM ON MORPHINE WITHDRAWAL SYMPTOMS IN ADULT MALE MICE

Author(s)

AHMADI RAMESH | PISHGHADAM SAEEDE | MIRALI AMIN | Issue Writer Certificate

Keywords

HYPERICUM SCABRUMQ2

MORPHINE WITHDRAWAL SYMPTOMSQ2

MALE MICEQ2

Abstract

Background: Nowadays the medicinal herbs are considerably used to decrease the symptoms of drug withdrawal syndrome and facilitate this process. According to anti-pain and anti-anxiety effects of HYPERICUM SCABRUM, this research was done to study acute effects of hydroalcoholic extract of HYPERICUM SCABRUM on MORPHINE WITHDRAWAL SYMPTOMS in adult male NMRI mice strain.Materials and methods: In this experimental study, adult MALE MICE were divided into two main groups of control and experimental. The control group received morphine and naloxone. The experimental group received morphine and 10, 20 and 30 mg/kg doses of HYPERICUM SCABRUM. During three days and three times of each day with five hours intervals, the animal received 10, 20 and 30 mg/kg doses respectively and in the fourth day they received 40 mg/kg drug subcutaneously (Marshall method). In chronic method, 10, 20 and 30 mg/kg doses of Hypericum were injected to three groups of morphine intraperitoneally. To induce withdrawal syndrome in all groups, three hours after the last morphine injection, one dose of 5mg/kg of naloxone was injected intraperitoneally. In all groups, after naloxone injection the symptoms of morphine withdrawal including jumping, standing on two feet, climbing up the wall and weight loss was considered.Results: Acute injection of the HYPERICUM SCABRUM could significantly decrease the symptoms of morphine withdrawal in comparison with morphine group.Conclusion: Decreasing symptoms of morphine withdrawal probably ordinates from HYPERICUM SCABRUM opioid-like effects.

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APA: Copy

AHMADI, RAMESH, PISHGHADAM, SAEEDE, & MIRALI, AMIN. (2014). THE EFFECT OF HYDROALCHOHOLIC EXTRACT OF HYPERICUM SCABRUM ON MORPHINE WITHDRAWAL SYMPTOMS IN ADULT MALE MICE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 24(3), 143-147. SID. https://sid.ir/paper/98818/en

Vancouver: Copy

AHMADI RAMESH, PISHGHADAM SAEEDE, MIRALI AMIN. THE EFFECT OF HYDROALCHOHOLIC EXTRACT OF HYPERICUM SCABRUM ON MORPHINE WITHDRAWAL SYMPTOMS IN ADULT MALE MICE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2014;24(3):143-147. Available from: https://sid.ir/paper/98818/en

IEEE: Copy

RAMESH AHMADI, SAEEDE PISHGHADAM, and AMIN MIRALI, “THE EFFECT OF HYDROALCHOHOLIC EXTRACT OF HYPERICUM SCABRUM ON MORPHINE WITHDRAWAL SYMPTOMS IN ADULT MALE MICE,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 24, no. 3, pp. 143–147, 2014, [Online]. Available: https://sid.ir/paper/98818/en

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