A COMPARATIVE STUDY BETWEEN SABRIL (VIGABATRIN) AND ACTH IN TREATMENT OF INFANTILE SPASMS

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AMIR SALARI S.; GHOFRANI M.

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Journal: Iranian Journal of Pediatrics Year:2003 | Volume:12 | Issue:4 Page(s): 37-41

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Title

A COMPARATIVE STUDY BETWEEN SABRIL (VIGABATRIN) AND ACTH IN TREATMENT OF INFANTILE SPASMS

Author(s)

AMIR SALARI S. | GHOFRANI M. | Issue Writer Certificate

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Abstract

Infantile spasms (IS) is an age specific epileptic syndrome. With respect to poor response of IS to conventional antiepileptic drugs, scientists tend to find new effective drugs. In this study, 50 infants with IS in the age group of 2-24 months, were divided randomly into two equal groups, treated with Sabril or ACTH and compared for clinical efficacy and drug side effects. After sixth week of treatment in Sabril group there was 28% complete remission and 40% reduction in seizure frequencies while in ACTH group there was 40.9% complete remission and 45.5% reduction in seizure frequencies, showing no significant difference between clinical responses in the two groups. Drug side effects were seen in 16% of patients in Sabril group and 81.8% of those in ACTH group. These differences were significant from statistical point of view. Unfortunately, it is impossible to evaluate visual field constriction, a probable irreversible side effect of Sabril. This justifies the use ACTH as the first line of treatment in IS.

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APA: Copy

AMIR SALARI, S., & GHOFRANI, M.. (2003). A COMPARATIVE STUDY BETWEEN SABRIL (VIGABATRIN) AND ACTH IN TREATMENT OF INFANTILE SPASMS. IRANIAN JOURNAL OF PEDIATRICS, 12(4), 37-41. SID. https://sid.ir/paper/75867/en

Vancouver: Copy

AMIR SALARI S., GHOFRANI M.. A COMPARATIVE STUDY BETWEEN SABRIL (VIGABATRIN) AND ACTH IN TREATMENT OF INFANTILE SPASMS. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2003;12(4):37-41. Available from: https://sid.ir/paper/75867/en

IEEE: Copy

S. AMIR SALARI, and M. GHOFRANI, “A COMPARATIVE STUDY BETWEEN SABRIL (VIGABATRIN) AND ACTH IN TREATMENT OF INFANTILE SPASMS,” IRANIAN JOURNAL OF PEDIATRICS, vol. 12, no. 4, pp. 37–41, 2003, [Online]. Available: https://sid.ir/paper/75867/en

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