Cytotoxic effects investigation of nanomicelle and free curcuminoids against cancer and normal cells

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Zendehdel Elham; Gheybi Fatemeh; CHAMANI JAMSHIDKHAN; JAAFARI MAHMOUD REZA

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Journal: NANOMEDICINE RESEARCH JOURNAL Year:2019 | Volume:4 | Issue:2 Page(s): 63-68

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Title

Cytotoxic effects investigation of nanomicelle and free curcuminoids against cancer and normal cells

Author(s)

Zendehdel Elham | Gheybi Fatemeh | CHAMANI JAMSHIDKHAN | JAAFARI MAHMOUD REZA | Issue Writer Certificate

Keywords

Cancer Cell

Curcumin

Micelle

MTT Assay

Abstract

Curcumin, which is derived from the turmeric rhizomes (curcuma longa) as a natural polyphenol, is a substantially lipophilic molecule. This commonly used substance is employed as a coloring agent and spice in food and contains potent antioxidant, as well as anti-inflammatory, and anti-proliferative tumor activities. The developed nanoMicelle formulations of Curcumin are used to promote the bio-availability and solubility of the above-mentioned lipophilic molecule. The present investigation aimed to examine the anti-proliferative activity of nanoMicelle and free Curcuminoids by using different cancer and normal cells using a tetrazolium dye-based assay. To this end, various cell lines were treated with nanoMicelle or free Curcuminoids at different concentration of 5, 10, 20, 30, and 40 μ M for 48 hours at 37 oC. Our results demonstrated that the half maximal inhibitory concentrations of the micellar form of Curcuminoids for different Cancer Cell lines were as high as its levels measured for its free form but in normal cells, the toxicity of nanoMicelles is lower than free form of Curcuminoids.

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APA: Copy

Zendehdel, Elham, Gheybi, Fatemeh, CHAMANI, JAMSHIDKHAN, & JAAFARI, MAHMOUD REZA. (2019). Cytotoxic effects investigation of nanomicelle and free curcuminoids against cancer and normal cells. NANOMEDICINE RESEARCH JOURNAL, 4(2), 63-68. SID. https://sid.ir/paper/763296/en

Vancouver: Copy

Zendehdel Elham, Gheybi Fatemeh, CHAMANI JAMSHIDKHAN, JAAFARI MAHMOUD REZA. Cytotoxic effects investigation of nanomicelle and free curcuminoids against cancer and normal cells. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2019;4(2):63-68. Available from: https://sid.ir/paper/763296/en

IEEE: Copy

Elham Zendehdel, Fatemeh Gheybi, JAMSHIDKHAN CHAMANI, and MAHMOUD REZA JAAFARI, “Cytotoxic effects investigation of nanomicelle and free curcuminoids against cancer and normal cells,” NANOMEDICINE RESEARCH JOURNAL, vol. 4, no. 2, pp. 63–68, 2019, [Online]. Available: https://sid.ir/paper/763296/en

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