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Information Journal Paper

Title

PREVALENCE DETERMINATION OF SICKLE CELL TRAIT BY PREMARITAL SCREENING AT ISFAHAN HALASSEMIA PREVENTION CENTER

Pages

  19-22

Abstract

 Purpose: Despite the expansion of thalassemia control programs in Iran, there has been no particular attention to sickle cell anemia, while, there is considerable spread of the sickle cell disease in neighboring countries and some of the southern districts of Iran. In one of the villages of Isfahan, there has been a report of a prevalence of 8.33%. Following the determination of such a high incidence of SICKLE CELL TRAIT in that area and the possibility of the coexistence of sickle cell and beta thalassemia minor that may lead to giving birth to sickle cell babies, we decided to determine the prevalence of SICKLE CELL TRAIT in the couples referring to Isfahan Thalassemia Prevention Center (ITPC) for premarriage tests.Materials and Methods; For this purpose, we studied 500 couples ( 500 men and 500 woman) referred to the ITPC in Autumn 1999 by the screened them for SICKLING TEST .Then the suspicious cases were confirmed by the HEMOGLOBIN ELECTROPHORESIS. Results: 3% of individuals had suspicious SICKLING TEST. but after the HEMOGLOBIN ELECTROPHORESIS, they showed no positive results.Discussion and conclusion: From this survey it can be concluded that the sickle cell incidence is very low in Isfahan city. But, because of a prevalence of 8.33% in one of the villages, the regions with high prevalence must be determined by carrying out the screening test and the couples should become aware in this regard before the marriage at the counseling centers. They must either be encouraged to avoid marriage if their test was positive, or the required prenatal diagnesis test should be applied for them to prevent the increase of the number of affected individnals by the thalasemia and hemogolobinopathies.

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    APA: Copy

    AMINI, A., NADALI, FATEMEH, & DEREIKVAND, G.. (2005). PREVALENCE DETERMINATION OF SICKLE CELL TRAIT BY PREMARITAL SCREENING AT ISFAHAN HALASSEMIA PREVENTION CENTER . PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 7(2), 19-22. SID. https://sid.ir/paper/81152/en

    Vancouver: Copy

    AMINI A., NADALI FATEMEH, DEREIKVAND G.. PREVALENCE DETERMINATION OF SICKLE CELL TRAIT BY PREMARITAL SCREENING AT ISFAHAN HALASSEMIA PREVENTION CENTER . PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2005;7(2):19-22. Available from: https://sid.ir/paper/81152/en

    IEEE: Copy

    A. AMINI, FATEMEH NADALI, and G. DEREIKVAND, “PREVALENCE DETERMINATION OF SICKLE CELL TRAIT BY PREMARITAL SCREENING AT ISFAHAN HALASSEMIA PREVENTION CENTER ,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 7, no. 2, pp. 19–22, 2005, [Online]. Available: https://sid.ir/paper/81152/en

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