CHRONIC EXPOSURE OF FEMALE RATS WITH MORPHINE BEFORE THE GESTATION CAUSES REDUCTION OF SPATIAL MEMORY AND INCREASE OF VULNERABILITY TO OPIATE INTAKE IN NEXT GENERATION OFFSPRING

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MOULAEI NEDA; SADEGH MEHDI; PALIZVAN MOHAMMAD REZA; MONDANIZADEH MAHDIEH; HAERI NARGES AL SADAT

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Journal: Journal of Sabzevar University of Medical Sciences Year:2017 | Volume:24 | Issue:1 Page(s): 17-27

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Title

CHRONIC EXPOSURE OF FEMALE RATS WITH MORPHINE BEFORE THE GESTATION CAUSES REDUCTION OF SPATIAL MEMORY AND INCREASE OF VULNERABILITY TO OPIATE INTAKE IN NEXT GENERATION OFFSPRING

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ADDICTIONQ2

DEPENDENCEQ2

MEMORYQ2

OPIOIDSQ2

RATQ2

Abstract

Background & Objectives: According to the increasing OPIOIDS abuse between women and pathophysiological effects of chronic exposure of OPIOIDS on mothers which might indirectly affect their offspring, herein, consequences of chronic morphine consumption and its withdrawal before the gestation was investigated on spatial MEMORY, avoidance MEMORY and vulnerability to morphine intake in offspring of first generation.Materials & Methods: Twelve female Wistar RATs were randomly divided into two groups. Morphine mothers group received morphine solution (0.4 mg/ml) for two months. Control mothers group received tab water. One month after stopping morphine consumption, mating was occurred. After the parturition, offspring was divided in separated male and female groups and was used as the target groups of the study. Spatial MEMORY through Water Maze, avoidance MEMORY through Shuttle Box and vulnerability to morphine intake through voluntary consumption of morphine solution were investigated.Results: Mean of morphine solution consumption in male and female offspring of morphine mothers was significantly higher in compare to male and female offspring of control mothers (P<0.05). Results of learning in Water Maze revealed that male offspring of morphine mothers significantly spent more time and distance to find the platform in compare with male offspring of control (P<0.01). Also, in retention test, male offspring of morphine mothers cross the location of platform significantly fewer than male offspring of control (P<0.001). There was no significant differences in avoidance learning between experimental groups (P<0.05).Conclusion: Our study revealedchronic morphine consumption before the gestation causes damage of spatial MEMORY in male offspring and also increases vulnerability to opiate intake of male and female offspring.

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APA: Copy

MOULAEI, NEDA, SADEGH, MEHDI, PALIZVAN, MOHAMMAD REZA, MONDANIZADEH, MAHDIEH, & HAERI, NARGES AL SADAT. (2017). CHRONIC EXPOSURE OF FEMALE RATS WITH MORPHINE BEFORE THE GESTATION CAUSES REDUCTION OF SPATIAL MEMORY AND INCREASE OF VULNERABILITY TO OPIATE INTAKE IN NEXT GENERATION OFFSPRING. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 24(1), 17-27. SID. https://sid.ir/paper/82314/en

Vancouver: Copy

MOULAEI NEDA, SADEGH MEHDI, PALIZVAN MOHAMMAD REZA, MONDANIZADEH MAHDIEH, HAERI NARGES AL SADAT. CHRONIC EXPOSURE OF FEMALE RATS WITH MORPHINE BEFORE THE GESTATION CAUSES REDUCTION OF SPATIAL MEMORY AND INCREASE OF VULNERABILITY TO OPIATE INTAKE IN NEXT GENERATION OFFSPRING. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;24(1):17-27. Available from: https://sid.ir/paper/82314/en

IEEE: Copy

NEDA MOULAEI, MEHDI SADEGH, MOHAMMAD REZA PALIZVAN, MAHDIEH MONDANIZADEH, and NARGES AL SADAT HAERI, “CHRONIC EXPOSURE OF FEMALE RATS WITH MORPHINE BEFORE THE GESTATION CAUSES REDUCTION OF SPATIAL MEMORY AND INCREASE OF VULNERABILITY TO OPIATE INTAKE IN NEXT GENERATION OFFSPRING,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 1, pp. 17–27, 2017, [Online]. Available: https://sid.ir/paper/82314/en

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